TY - CHAP
T1 - Recovery from chronic diseases of consciousness: State of the art in neuromodulation for persistent vegetative state and minimally conscious state
AU - Iacopino, Domenico
AU - Zhong, Jun
AU - La Rocca, Giuseppe
AU - Mattogno, Pier Paolo
AU - Pappalardo, Gaetano
AU - Signorelli, Francesco
AU - Iacopino, Gerardo
AU - Pappalardo, Gaetano
AU - Barbagallo, Giuseppe
AU - Visocchi, Massimiliano
PY - 2017
Y1 - 2017
N2 - Chronic diseases of consciousness (CDC) can still be considered a challenging frontier for modern medicine, probably because of their not completely understood physiopathological mechanisms. Following encouraging evidence on cerebral hemodynamics, some authors have hypothesized a role for neuromodulation in the treatment of CDC patients. In the past 40 years, spinal cord stimulation (SCS) and deep brain stimulation (DBS) have been used experimentally for the treatment of patients in a severe altered state of consciousness, with some interesting but not conclusive results. The present review summarizes the data currently available in the literature on this particular and debated topic. On these grounds, further clinical studies are needed to better understand the altered dynamics of neuronal network circuits in CDC patients as a step towards novel therapeutic strategies.
AB - Chronic diseases of consciousness (CDC) can still be considered a challenging frontier for modern medicine, probably because of their not completely understood physiopathological mechanisms. Following encouraging evidence on cerebral hemodynamics, some authors have hypothesized a role for neuromodulation in the treatment of CDC patients. In the past 40 years, spinal cord stimulation (SCS) and deep brain stimulation (DBS) have been used experimentally for the treatment of patients in a severe altered state of consciousness, with some interesting but not conclusive results. The present review summarizes the data currently available in the literature on this particular and debated topic. On these grounds, further clinical studies are needed to better understand the altered dynamics of neuronal network circuits in CDC patients as a step towards novel therapeutic strategies.
UR - http://hdl.handle.net/10447/484855
M3 - Chapter
SN - 978-3-319-39545-6; 978-3-319-39546-3
T3 - ACTA NEUROCHIRURGICA. SUPPLEMENTUM
SP - 19
EP - 25
BT - Trends in Reconstructive Neurosurgery: Neurorehabilitation, Restoration and Reconstruction
ER -