Abstract
Studies of the the three-dimensional quantitativestructure–activity relationships for ninety-five c-kit tyrosinekinase inhibitors were performed. Based on a cocrystallizedcompound (1 T46), known inhibitors werealigned with c-kit by induced-fit docking, and multipletraining/test set splitting was performed to validate theselected pharmacophore model. The best pharmacophoremodel consisted of five features: one hydrogen-bond donorand four aromatic rings. Reliable statistics were obtained(R2=0.95, Rpred2=0.75), and the model was validated byusing it to select c-kit inhibitors from a database; 82.1% ofthe hits it retrieved were active. Accordingly, our model canbe reliably used to identify new c-kit inhibitors, and canprovide useful information when designing new inhibitors.
Lingua originale | English |
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pagine (da-a) | 2885-2895 |
Numero di pagine | 10 |
Rivista | Journal of Molecular Modeling |
Volume | 18 |
Stato di pubblicazione | Published - 2012 |
All Science Journal Classification (ASJC) codes
- ???subjectarea.asjc.1500.1503???
- ???subjectarea.asjc.1700.1706???
- ???subjectarea.asjc.1600.1606???
- ???subjectarea.asjc.1600.1605???
- ???subjectarea.asjc.1700.1703???
- ???subjectarea.asjc.1600.1604???