Recent development in fluorinated antibiotics

Risultato della ricerca: Chapter

Abstract

This chapter presents the most recent results in the development of fluorinated antibioticsby taking into consideration modern challenges of multidrug-resistant pathogens. After a brief introduction on the direct and indirect effects of fluorine and fluorinated moieties in regulating biological activity, the chapter is developed in three main subsections discussing the two major classes of fluorinated antibiotics, fluoroquinolones and oxazolidinones, plus an overview of recent research on the antibiotic activity of fluorinated analogs of tetracyclines, peptidomimetics, triazoles, and nucleosides. Discussed aspects include: (1) Synthesis and challenges posed by the introduction of fluorinated moieties in specific positions of the main scaffold; (2) mechanism of action and structure–activity relationships in which the introduction or modification of fluorinated substituent is crucial to control efficacy; and (3) resistance mechanisms and solutions to treat resistant pathogens.
Lingua originaleEnglish
Titolo della pubblicazione ospiteFluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series
Pagine213-239
Numero di pagine27
Stato di pubblicazionePublished - 2019

Fingerprint

Antibiotics
Efficacy
Fluorine

Cita questo

Buscemi, S., Pibiri, I., Palumbo Piccionello, A., & Pace, A. (2019). Recent development in fluorinated antibiotics. In Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series (pagg. 213-239)

Recent development in fluorinated antibiotics. / Buscemi, Silvestre; Pibiri, Ivana; Palumbo Piccionello, Antonio; Pace, Andrea.

Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series. 2019. pag. 213-239.

Risultato della ricerca: Chapter

Buscemi, S, Pibiri, I, Palumbo Piccionello, A & Pace, A 2019, Recent development in fluorinated antibiotics. in Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series. pagg. 213-239.
Buscemi S, Pibiri I, Palumbo Piccionello A, Pace A. Recent development in fluorinated antibiotics. In Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series. 2019. pag. 213-239
Buscemi, Silvestre ; Pibiri, Ivana ; Palumbo Piccionello, Antonio ; Pace, Andrea. / Recent development in fluorinated antibiotics. Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series. 2019. pagg. 213-239
@inbook{1acc4036f2d84b4c88290b0fe8ac82c4,
title = "Recent development in fluorinated antibiotics",
abstract = "This chapter presents the most recent results in the development of fluorinated antibioticsby taking into consideration modern challenges of multidrug-resistant pathogens. After a brief introduction on the direct and indirect effects of fluorine and fluorinated moieties in regulating biological activity, the chapter is developed in three main subsections discussing the two major classes of fluorinated antibiotics, fluoroquinolones and oxazolidinones, plus an overview of recent research on the antibiotic activity of fluorinated analogs of tetracyclines, peptidomimetics, triazoles, and nucleosides. Discussed aspects include: (1) Synthesis and challenges posed by the introduction of fluorinated moieties in specific positions of the main scaffold; (2) mechanism of action and structure–activity relationships in which the introduction or modification of fluorinated substituent is crucial to control efficacy; and (3) resistance mechanisms and solutions to treat resistant pathogens.",
author = "Silvestre Buscemi and Ivana Pibiri and {Palumbo Piccionello}, Antonio and Andrea Pace",
year = "2019",
language = "English",
isbn = "978-0-12-812733-9",
pages = "213--239",
booktitle = "Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series",

}

TY - CHAP

T1 - Recent development in fluorinated antibiotics

AU - Buscemi, Silvestre

AU - Pibiri, Ivana

AU - Palumbo Piccionello, Antonio

AU - Pace, Andrea

PY - 2019

Y1 - 2019

N2 - This chapter presents the most recent results in the development of fluorinated antibioticsby taking into consideration modern challenges of multidrug-resistant pathogens. After a brief introduction on the direct and indirect effects of fluorine and fluorinated moieties in regulating biological activity, the chapter is developed in three main subsections discussing the two major classes of fluorinated antibiotics, fluoroquinolones and oxazolidinones, plus an overview of recent research on the antibiotic activity of fluorinated analogs of tetracyclines, peptidomimetics, triazoles, and nucleosides. Discussed aspects include: (1) Synthesis and challenges posed by the introduction of fluorinated moieties in specific positions of the main scaffold; (2) mechanism of action and structure–activity relationships in which the introduction or modification of fluorinated substituent is crucial to control efficacy; and (3) resistance mechanisms and solutions to treat resistant pathogens.

AB - This chapter presents the most recent results in the development of fluorinated antibioticsby taking into consideration modern challenges of multidrug-resistant pathogens. After a brief introduction on the direct and indirect effects of fluorine and fluorinated moieties in regulating biological activity, the chapter is developed in three main subsections discussing the two major classes of fluorinated antibiotics, fluoroquinolones and oxazolidinones, plus an overview of recent research on the antibiotic activity of fluorinated analogs of tetracyclines, peptidomimetics, triazoles, and nucleosides. Discussed aspects include: (1) Synthesis and challenges posed by the introduction of fluorinated moieties in specific positions of the main scaffold; (2) mechanism of action and structure–activity relationships in which the introduction or modification of fluorinated substituent is crucial to control efficacy; and (3) resistance mechanisms and solutions to treat resistant pathogens.

UR - http://hdl.handle.net/10447/391717

M3 - Chapter

SN - 978-0-12-812733-9

SP - 213

EP - 239

BT - Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals Progress in Fluorine Science Series

ER -