Recent advances in desmoid tumor therapy

Lorena Incorvaia, Giuseppe Badalamenti, Lorena Incorvaia, Marianna Silletta, Giuseppe Badalamenti, Andrea Napolitano, Alessandro Mazzocca, Alessandro Minelli, Francesca Baldo, Mariella Spalato Ceruso, Giuseppe Badalamenti, Bruno Vincenzi, Giuseppe Tonini, Daniele Santini, Daniele Santini, Gabriella Tonini

Risultato della ricerca: Articlepeer review

9 Citazioni (Scopus)


The desmoid tumor is a locally aggressive proliferative disease within the family of soft-tissue sarcomas. Despite its relatively good prognosis, the clinical management of desmoid tumors requires constant multidisciplinary evaluation due to its highly variable clinical behavior. Recently, active surveillance has being regarded as the appropriate strategy at diagnosis, as indolent persistence or spontaneous regressions are not uncommon. Here, we review the most recent advances in desmoid tumor therapy, including low-dose chemotherapy and treatment with tyrosine kinase inhibitors. We also explore the recent improvements in our knowledge of the molecular biology of this disease, which are leading to clinical trials with targeted agents.
Lingua originaleEnglish
pagine (da-a)1-13
Numero di pagine13
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1306???


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