Rational for statin use in psoriatic patients

Manfredi Rizzo, Grazyna Chodorowska, Kristian Reich, Aldona Pietrzak, Manfredi Rizzo, Marcin Trojnar, Jacek Szepietowski, Jerzy Mosiewicz

Risultato della ricerca: Article

13 Citazioni (Scopus)

Abstract

Psoriasis represents a common skin diseasewhich is clinically manifested by chronic cutaneous lesions. It has been observed that psoriasis is associated with an increased risk of cardiovascular diseases, which is contributed to the inappropriate lipid metabolism. Statins are commonly used in clinical practice to lower cholesterol concentration and, accordingly, decrease the individual risk of developing a cardiovascular episode. There have been reports that statin administration could also result in better management of psoriasis. The observed beneficial effects are contributed to the effects on lipid metabolism, including that in skin, as well as anti-inflammatory and immunomodulatory properties of statins. Simvastatin and atorvastatin were found to improve the clinical outcome in patients with psoriatic skin lesions. Clinically, the effectiveness of this novel treatment was confirmed by the significant reduction in PASI score. To date several cases have been reported in which atorvastatin or pravastatin worsened psoriasis. Based on these results, it seems that statins represent a promising class of medications which could be extensively used in psoriasis.
Lingua originaleEnglish
pagine (da-a)467-472
Numero di pagine6
RivistaArchives of Dermatological Research
Volume305
Stato di pubblicazionePublished - 2013

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Psoriasis
Skin
Lipid Metabolism
Simvastatin
Anti-Inflammatory Agents
Cardiovascular Diseases
Cholesterol
Atorvastatin Calcium

All Science Journal Classification (ASJC) codes

  • Dermatology

Cita questo

Rizzo, M., Chodorowska, G., Reich, K., Pietrzak, A., Rizzo, M., Trojnar, M., ... Mosiewicz, J. (2013). Rational for statin use in psoriatic patients. Archives of Dermatological Research, 305, 467-472.

Rational for statin use in psoriatic patients. / Rizzo, Manfredi; Chodorowska, Grazyna; Reich, Kristian; Pietrzak, Aldona; Rizzo, Manfredi; Trojnar, Marcin; Szepietowski, Jacek; Mosiewicz, Jerzy.

In: Archives of Dermatological Research, Vol. 305, 2013, pag. 467-472.

Risultato della ricerca: Article

Rizzo, M, Chodorowska, G, Reich, K, Pietrzak, A, Rizzo, M, Trojnar, M, Szepietowski, J & Mosiewicz, J 2013, 'Rational for statin use in psoriatic patients', Archives of Dermatological Research, vol. 305, pagg. 467-472.
Rizzo M, Chodorowska G, Reich K, Pietrzak A, Rizzo M, Trojnar M e altri. Rational for statin use in psoriatic patients. Archives of Dermatological Research. 2013;305:467-472.
Rizzo, Manfredi ; Chodorowska, Grazyna ; Reich, Kristian ; Pietrzak, Aldona ; Rizzo, Manfredi ; Trojnar, Marcin ; Szepietowski, Jacek ; Mosiewicz, Jerzy. / Rational for statin use in psoriatic patients. In: Archives of Dermatological Research. 2013 ; Vol. 305. pagg. 467-472.
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AU - Trojnar, Marcin

AU - Szepietowski, Jacek

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