Random forest analysis: a new approach for classication of Beta Thalassemia

In recent years, Thalassemia care providers started classifying patients as transfusion-dependent-Thalassemia (TDT) or non-transfusion-dependent-Thalassemia (NTDT) owing tothe established role of transfusion therapy in dening the clinical complication prole, althoughthis classication was also based on expert opinion and is limited by reliance on patients'currenttransfusion status. Starting from a vast set of variables indicating severity phenotype, throughthe use of both classication and clustering techniques we want to explore the presence oftwo (TDT vs NTDT) or more clusters, in order to approaching to a new denition for theclassication of Beta-Thalassemia in Thalassemia Syndromes (TS).