Raman spectroscopy technology to monitor the carotenoids in skin of thalassemia patients: a novel non-invasive tool relating oxidative stress with iron burden

Maria Antonia Livrea, Anna Maria Pintaudi, Luisa Tesoriere, Anna Perrone, Paolo Rigano, Aurelio Maggio, Alessandro Attanzio

Risultato della ricerca: Article

3 Citazioni (Scopus)

Abstract

In this work we approach the relationship between redox state and iron overload by noninvasive instrumental techniques.Intracardiac, liver iron and liver fibrosis have been monitored in transfusion-dependent thalassemia patients by magnetic resonance imaging and hepatic transient elastography examinations. These measurements have been matched with a non-invasive, and yet unexplored in clinical practice, evaluation of body’s oxidative stress through measurement of antioxidant carotenoids in skin, by a spectroscopic method based on Raman technology(RRS). The global body’s antioxidant status results from a balance between the level of antioxidants in cells and body fluids, including blood, and pro-oxidant species endogenously produced or coming from external sources. On this basis, the level of skin carotenoids can be considered a biomarker of the entire antioxidant status. In our work the use of RRS method provided information on the redox state of thalassemia patients, which was correlated with the iron status of the patients. Due to the highly adverse effects of accumulated iron, the novel, simple, non-invasive RRS to monitor dermal carotenoids with high compliance of the patients may be a useful tool for the management of thalassemia patients.
Lingua originaleEnglish
pagine (da-a)38-42
Numero di pagine5
RivistaThalassemia Reports
Volume4
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Hematology

Fingerprint Entra nei temi di ricerca di 'Raman spectroscopy technology to monitor the carotenoids in skin of thalassemia patients: a novel non-invasive tool relating oxidative stress with iron burden'. Insieme formano una fingerprint unica.

  • Cita questo