Raman Spectroscopic Measurements ofDermal Carotenoids in Breast Cancer Operated Patients ProvideEvidence for the Positive Impact of a Dietary Regimen Rich inFruit and Vegetables on Body Oxidative Stress and BCPrognostic Anthropometric Parameters: A Five-Year Study

Carla Gentile, Luisa Tesoriere, Maria Antonia Livrea, Anna Perrone, Anna Maria Pintaudi, Giuseppe Carruba, Traina, Alessandro Attanzio, Giuseppe Carruba

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5 Citazioni (Scopus)

Abstract

Dermal carotenoids are a feasible marker of the body antioxidative network and may reveal a moderate to severe imbalance of theredox status, thereby providing indication of individual oxidative stress. In this work noninvasive Resonance Raman Spectroscopy(RRS) measurements of skin carotenoids (skin carotenoid score (SCS)) were used to provide indications of individual oxidativestress, each year for five years, in 71 breast cancer (BC) patients at high risk of recurrence. Patients’ SCS has been correlated withparameters relevant to BC risk, waist circumference (WC), and body mass index (BMI), in the aim of monitoring the effect ofa dietary regimen intended to positively affect BC risk factors. The RRS methodological approach in BC patients appeared frompositive correlation between patients’ SCS and blood level of lycopene. The level of skin carotenoids was inversely correlated withthe patients’ WC and BMI. At the end of the 5 y observation BC patients exhibited a significant reduction of WC and BMI andincrease of SCS, when strictly adhering to the dietary regimen. In conclusion, noninvasive measurements of skin carotenoids can(i) reveal an oxidative stress condition correlated with parameters of BC risk and (ii) monitor dietary-related variations in BCpatients.
Lingua originaleEnglish
Numero di pagine8
RivistaOxidative Medicine and Cellular Longevity
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Ageing
  • Cell Biology

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