A scalable, single step, synthetic approach for the manufacture of biocompatible, functionalized microgels and nanogels hasbeen developed. Pulsed EB irradiation of PVP aqueous solutions, at relatively low energies per pulse and doses within the sterilizationdose range, has led to a variety of ‘as-born’ sterile, functional nanostructures that exhibit a combination of favourable propertieswhich make them suitable as biomedical nanocarriers. Reactive functional groups have been generated by graft copolymerization offunctional acrylic monomers. These groups can be used to attach fluorescent probes to the NPs, to bioconjugate ligands of specificcell receptors and to incorporate therapeutics. To support the applicability of these nanogels, as well as their preparation procedure, forbiomedical use, several different biocompatibility tests have been carried out.
|Titolo della pubblicazione ospite||IAEA RADIATION TECHNOLOGY REPORTS No. 5: Nanoscale Radiation Engineering of Advanced Materials for Potential Biomedical Applications|
|Numero di pagine||11|
|Stato di pubblicazione||Published - 2015|