Quantitative EEG differentiate Multiple Sclerosis with and without Cognitive Impairment from healthy controls at the beginning of the disease: preliminary data

Luppino, V.

Risultato della ricerca: Article

Abstract

Background and aims: The present study aims to asses possible qEEG differences between newly diagnosed Multiple Sclerosis (MS) patients with or without Cognitive Impairment (CI). Methods: We enrolled 13 patiens (18-5 years old) treated with first-line drugs for <6 months, and 16 healthy controls. All subjects underwent neuropsychological assessment including BICAMS and BDI. EEG recordings were performed during a cognitive task (computerised “SDMT” subtest of BICAMS) and at rest (5 minutes before and after task). Based on neuropsychological assessment patients were diagnosed as with -MSCI group- or without -MS group- cognitive impairment: only data from MSCI patients matched for sex, age (±5 years) and education to both an MS patient and a healthy control were analysed. Power spectrum analysis (theta, alpha, beta bands and sub-bands) were performed (EEGlab extension for MatLab). Data were log-transformed and analysed through repeated measures ANOVA. Results: A significant interaction group (MSCI, MS, control) x condition (rest, task) x band (alpha, beta, theta) was observed. Post-hoc analyses showed significant differences between MSCI and both MS and controls in all EEG bands at rest (p<.05), whereas MS patients significantly differed from controls only in alpha2 and beta bands (p<.05). In task condition MSCI significantly differed from controls in alpha and beta bands, whereas MS in theta band (p<.05). Conclusion: If confirmed in larger series, our results seem to support the hypothesis that qEEG differences exist among MSCI, MS and healthy controls, opening to a new possible neurophysiological hallmark of cognitive impairment in MS patients. Disclosure: Nothing to disclose
Lingua originaleEnglish
pagine (da-a)255-255
Numero di pagine1
RivistaEuropean Journal of Neurology. 25, S2 p
Volume25
Stato di pubblicazionePublished - 2018

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@article{06c2f266e5d44a13b6659cb6f7f92515,
title = "Quantitative EEG differentiate Multiple Sclerosis with and without Cognitive Impairment from healthy controls at the beginning of the disease: preliminary data",
abstract = "Background and aims: The present study aims to asses possible qEEG differences between newly diagnosed Multiple Sclerosis (MS) patients with or without Cognitive Impairment (CI). Methods: We enrolled 13 patiens (18-5 years old) treated with first-line drugs for <6 months, and 16 healthy controls. All subjects underwent neuropsychological assessment including BICAMS and BDI. EEG recordings were performed during a cognitive task (computerised “SDMT” subtest of BICAMS) and at rest (5 minutes before and after task). Based on neuropsychological assessment patients were diagnosed as with -MSCI group- or without -MS group- cognitive impairment: only data from MSCI patients matched for sex, age (±5 years) and education to both an MS patient and a healthy control were analysed. Power spectrum analysis (theta, alpha, beta bands and sub-bands) were performed (EEGlab extension for MatLab). Data were log-transformed and analysed through repeated measures ANOVA. Results: A significant interaction group (MSCI, MS, control) x condition (rest, task) x band (alpha, beta, theta) was observed. Post-hoc analyses showed significant differences between MSCI and both MS and controls in all EEG bands at rest (p<.05), whereas MS patients significantly differed from controls only in alpha2 and beta bands (p<.05). In task condition MSCI significantly differed from controls in alpha and beta bands, whereas MS in theta band (p<.05). Conclusion: If confirmed in larger series, our results seem to support the hypothesis that qEEG differences exist among MSCI, MS and healthy controls, opening to a new possible neurophysiological hallmark of cognitive impairment in MS patients. Disclosure: Nothing to disclose",
author = "{Luppino, V.} and Pierangelo Sardo and Giuseppe Salemi and Giuseppe Ferraro and Massimo Gangitano and Paolo Ragonese and Giuseppe Giglia and Sabrina Realmuto and Bruna Nucera",
year = "2018",
language = "English",
volume = "25",
pages = "255--255",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell Publishing Ltd",

}

TY - JOUR

T1 - Quantitative EEG differentiate Multiple Sclerosis with and without Cognitive Impairment from healthy controls at the beginning of the disease: preliminary data

AU - Luppino, V.

AU - Sardo, Pierangelo

AU - Salemi, Giuseppe

AU - Ferraro, Giuseppe

AU - Gangitano, Massimo

AU - Ragonese, Paolo

AU - Giglia, Giuseppe

AU - Realmuto, Sabrina

AU - Nucera, Bruna

PY - 2018

Y1 - 2018

N2 - Background and aims: The present study aims to asses possible qEEG differences between newly diagnosed Multiple Sclerosis (MS) patients with or without Cognitive Impairment (CI). Methods: We enrolled 13 patiens (18-5 years old) treated with first-line drugs for <6 months, and 16 healthy controls. All subjects underwent neuropsychological assessment including BICAMS and BDI. EEG recordings were performed during a cognitive task (computerised “SDMT” subtest of BICAMS) and at rest (5 minutes before and after task). Based on neuropsychological assessment patients were diagnosed as with -MSCI group- or without -MS group- cognitive impairment: only data from MSCI patients matched for sex, age (±5 years) and education to both an MS patient and a healthy control were analysed. Power spectrum analysis (theta, alpha, beta bands and sub-bands) were performed (EEGlab extension for MatLab). Data were log-transformed and analysed through repeated measures ANOVA. Results: A significant interaction group (MSCI, MS, control) x condition (rest, task) x band (alpha, beta, theta) was observed. Post-hoc analyses showed significant differences between MSCI and both MS and controls in all EEG bands at rest (p<.05), whereas MS patients significantly differed from controls only in alpha2 and beta bands (p<.05). In task condition MSCI significantly differed from controls in alpha and beta bands, whereas MS in theta band (p<.05). Conclusion: If confirmed in larger series, our results seem to support the hypothesis that qEEG differences exist among MSCI, MS and healthy controls, opening to a new possible neurophysiological hallmark of cognitive impairment in MS patients. Disclosure: Nothing to disclose

AB - Background and aims: The present study aims to asses possible qEEG differences between newly diagnosed Multiple Sclerosis (MS) patients with or without Cognitive Impairment (CI). Methods: We enrolled 13 patiens (18-5 years old) treated with first-line drugs for <6 months, and 16 healthy controls. All subjects underwent neuropsychological assessment including BICAMS and BDI. EEG recordings were performed during a cognitive task (computerised “SDMT” subtest of BICAMS) and at rest (5 minutes before and after task). Based on neuropsychological assessment patients were diagnosed as with -MSCI group- or without -MS group- cognitive impairment: only data from MSCI patients matched for sex, age (±5 years) and education to both an MS patient and a healthy control were analysed. Power spectrum analysis (theta, alpha, beta bands and sub-bands) were performed (EEGlab extension for MatLab). Data were log-transformed and analysed through repeated measures ANOVA. Results: A significant interaction group (MSCI, MS, control) x condition (rest, task) x band (alpha, beta, theta) was observed. Post-hoc analyses showed significant differences between MSCI and both MS and controls in all EEG bands at rest (p<.05), whereas MS patients significantly differed from controls only in alpha2 and beta bands (p<.05). In task condition MSCI significantly differed from controls in alpha and beta bands, whereas MS in theta band (p<.05). Conclusion: If confirmed in larger series, our results seem to support the hypothesis that qEEG differences exist among MSCI, MS and healthy controls, opening to a new possible neurophysiological hallmark of cognitive impairment in MS patients. Disclosure: Nothing to disclose

UR - http://hdl.handle.net/10447/308095

M3 - Article

VL - 25

SP - 255

EP - 255

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

ER -