Quantification of Different Regulatory Pathways Contributing to Heartbeat Dynamics during Multiple Stimuli: A Proof of the Concept

Luca Faes, Riccardo Barbieri, Gaetano Valenza, Michal Javorka, Alberto Greco, Shadi Ghiasi, Barbieri, Enzo Pasquale Scilingo

Risultato della ricerca: Conference contribution

2 Citazioni (Scopus)


The dynamical interplay between brain and heart is mediated by several feedback mechanisms including the central autonomic network and baroreflex loop at a peripheral level, also for a short-term regulation. State of the art focused on the characterization of each regulatory pathway through a single stressor elicitation. However, no studies targeted the actual quantification of different mediating routes leading to the generation of heartbeat dynamics, particularly in case of combined exogenous stimuli. In this study, we propose a new approach based on computational modeling to quantify the contribution of multiple concurrent stimuli in modulating cardiovascular dynamics. In this preliminary attempt, the model estimates the high-frequency power of heartbeat dynamics, and derives disentangling coefficients quantifying the effect of multiple elicitations. Model evaluation is performed on healthy rate variability (HRV) series from fourteen healthy subjects undergoing physical (tilt-table) and mental stressors (aritmetics), as well as their combined administration. Results indicate that, at a group-wise level, in base of concurrent physical and mental elicitations, the physical stressor contributes for the 85% of the resulting heartbeat dynamics. These findings are in agreement with the current knowledge on heartbeat regulatory systems, providing valuable perspectives on the quantification of underlying generative mechanisms of HRV.
Lingua originaleEnglish
Titolo della pubblicazione ospiteProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Numero di pagine4
Stato di pubblicazionePublished - 2019

Serie di pubblicazioni


All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.1700.1711???
  • ???subjectarea.asjc.2200.2204???
  • ???subjectarea.asjc.1700.1707???
  • ???subjectarea.asjc.2700.2718???


Entra nei temi di ricerca di 'Quantification of Different Regulatory Pathways Contributing to Heartbeat Dynamics during Multiple Stimuli: A Proof of the Concept'. Insieme formano una fingerprint unica.

Cita questo