Quality of life following urinary diversion: Orthotopic ileal neobladder versus ileal conduit. A multicentre study among long-term, female bladder cancer survivors

Alchiede Simonato, Paolo Verze, Cristina Lonardi, Massimo Iafrate, Carolina D'Elia, Pierfrancesco Bassi, Francesco Visalli, Omar Saleh, Laura Toffoli, Antonio Porcaro, Davide De Marchi, Giovanni Cacciamani, Marco Racioppi, Mauro Niero, Mauro Gacci, Maria Angela Cerruto, Stefano Ciciliato, Alchiede Simonato, Ciro Imbimbo, Sergio SerniVincenzo Mirone, Renato Talamini, Salvatore Siracusano, Walter Artibani, Vincenzo De Marco, Paolo Verze

Risultato della ricerca: Articlepeer review

6 Citazioni (Scopus)

Abstract

Introduction: Women undergoing radical cystectomy (RC) followed by urinary diversion (UD) for bladder cancer experience a substantial reduction in health-related quality of life (HRQOL). At present, studies comparing long-term QOL outcomes for different UD methods, needed to inform evidence-based choices of bladder reconstruction for female patients, are sparse. Our objective was to compare two common UD methods in terms of their HRQOL outcomes in women. Materials and methods: We retrospectively analysed HRQOL in 73 consecutive female bladder cancer patients having undergone orthotopic ileal neobladder (IONB, N = 24) or ileal conduit (IC, N = 49) following RC between 2007 and 2013 in six Italian academic urological centres. Patients had no evidence of tumour recurrence and were actively followed up. Validated Italian versions of the European Organisation for Research and Treatment of Cancer (EORTC) generic (QLQ-C30) and bladder-cancer-specific (QLQ-BLM30) questionnaires were used to evaluate HRQOL. Results: Patients in the IONB group were significantly younger than those in the IC group (median age: 67 and 73 years, respectively, p = 0.02). Barring that, the two groups did not present statistically significant differences in median length of follow-up (43 vs 54 months), pathological stage, grading of the neoplasm, or adjuvant chemo - or radiotherapy. No significant differences in QOL were found between the groups, with the exception of financial difficulties, affecting IONB patients significantly more than IC patients (mean score on a scale of 0–100: 33.3 ± 29.5 vs 18.4 ± 19.3, respectively; p = 0.05). Conclusion: Financial difficulties was the only HRQOL item to differ between the two UD groups.
Lingua originaleEnglish
pagine (da-a)477-481
Numero di pagine5
RivistaEuropean Journal of Surgical Oncology
Volume45
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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