The pyrazolo[3,4-d]pyrimidine system shows a multitude of interesting pharmacological properties.Owing to the potential anti-inflammatory activity of 5-benzamido-pyrazolo[3,4-d]pyrimidin-4-one derivatives and considering the easy synthesis of this class of compounds, a set of new 5-benzamido-1H-pyrazolo[3,4-d]pyrimidin-4-ones has been prepared in 42-80% yields by reacting 5-aminopyrazole-4(N-benzoyl)carbohydrazide derivatives and the opportune triethylorthoesters.Compounds 8a, b, 10a–d, and 11a, b revealed a superior inhibitory profile against COX-2, whencompared to that of reference standards NS398 and indomethacin. Molecular modelling studies confirmed the obtained biological results.
|Numero di pagine||6|
|Rivista||Archiv der Pharmazie|
|Stato di pubblicazione||Published - 2009|
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
- Drug Discovery