Pyrazolo[3,4-d]pyrimidine Derivatives as COX-2 Selective Inhibitors: Synthesis and Molecular Modelling Studies

Risultato della ricerca: Articlepeer review

40 Citazioni (Scopus)

Abstract

The pyrazolo[3,4-d]pyrimidine system shows a multitude of interesting pharmacological properties.Owing to the potential anti-inflammatory activity of 5-benzamido-pyrazolo[3,4-d]pyrimidin-4-one derivatives and considering the easy synthesis of this class of compounds, a set of new 5-benzamido-1H-pyrazolo[3,4-d]pyrimidin-4-ones has been prepared in 42-80% yields by reacting 5-aminopyrazole-4(N-benzoyl)carbohydrazide derivatives and the opportune triethylorthoesters.Compounds 8a, b, 10a–d, and 11a, b revealed a superior inhibitory profile against COX-2, whencompared to that of reference standards NS398 and indomethacin. Molecular modelling studies confirmed the obtained biological results.
Lingua originaleEnglish
pagine (da-a)321-326
Numero di pagine6
RivistaArchiv der Pharmazie
Volume2009
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Drug Discovery

Fingerprint Entra nei temi di ricerca di 'Pyrazolo[3,4-d]pyrimidine Derivatives as COX-2 Selective Inhibitors: Synthesis and Molecular Modelling Studies'. Insieme formano una fingerprint unica.

Cita questo