Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement

Arturo Silvestri, Anna Maria Almerico, Antonino Lauria, Noemi Gambino, Ilenia Abbate, Giampaolo Barone, Chiara Patella

Risultato della ricerca: Article

11 Citazioni (Scopus)

Abstract

Derivatives of the new ring system pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.
Lingua originaleEnglish
pagine (da-a)5125-5128
Numero di pagine4
RivistaTetrahedron Letters
Volume49
Stato di pubblicazionePublished - 2008

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Intercalating Agents
Isomers
Derivatives
DNA
pyrimidine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement. / Silvestri, Arturo; Almerico, Anna Maria; Lauria, Antonino; Gambino, Noemi; Abbate, Ilenia; Barone, Giampaolo; Patella, Chiara.

In: Tetrahedron Letters, Vol. 49, 2008, pag. 5125-5128.

Risultato della ricerca: Article

Silvestri, A, Almerico, AM, Lauria, A, Gambino, N, Abbate, I, Barone, G & Patella, C 2008, 'Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement', Tetrahedron Letters, vol. 49, pagg. 5125-5128.
Silvestri A, Almerico AM, Lauria A, Gambino N, Abbate I, Barone G e altri. Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement. Tetrahedron Letters. 2008;49:5125-5128.
Silvestri, Arturo ; Almerico, Anna Maria ; Lauria, Antonino ; Gambino, Noemi ; Abbate, Ilenia ; Barone, Giampaolo ; Patella, Chiara. / Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement. In: Tetrahedron Letters. 2008 ; Vol. 49. pagg. 5125-5128.
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abstract = "Derivatives of the new ring system pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.",
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AU - Silvestri, Arturo

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AU - Lauria, Antonino

AU - Gambino, Noemi

AU - Abbate, Ilenia

AU - Barone, Giampaolo

AU - Patella, Chiara

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AB - Derivatives of the new ring system pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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