Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement

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Abstract

Derivatives of the new ring system pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.
Lingua originaleEnglish
pagine (da-a)5125-5128
Numero di pagine4
RivistaTetrahedron Letters
Volume49
Stato di pubblicazionePublished - 2008

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Intercalating Agents
Isomers
Derivatives
DNA
pyrimidine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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title = "Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement",
abstract = "Derivatives of the new ring system pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.",
author = "Arturo Silvestri and Almerico, {Anna Maria} and Antonino Lauria and Noemi Gambino and Ilenia Abbate and Giampaolo Barone and Chiara Patella",
year = "2008",
language = "English",
volume = "49",
pages = "5125--5128",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",

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T1 - Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement

AU - Silvestri, Arturo

AU - Almerico, Anna Maria

AU - Lauria, Antonino

AU - Gambino, Noemi

AU - Abbate, Ilenia

AU - Barone, Giampaolo

AU - Patella, Chiara

PY - 2008

Y1 - 2008

N2 - Derivatives of the new ring system pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.

AB - Derivatives of the new ring system pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.

UR - http://hdl.handle.net/10447/43922

M3 - Article

VL - 49

SP - 5125

EP - 5128

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

ER -