Pyrano[2,3-e]isoindol-2-ones, new angelicin heteroanalogues

Virginia Spano', Anna Carbone, Patrizia Diana, Girolamo Cirrincione, Paola Barraja, Alessia Salvador, Daniela Vedaldi, Francesco Dall'Acqua, Giampietro Viola

Risultato della ricerca: Articlepeer review

39 Citazioni (Scopus)

Abstract

A convenient synthesis of the pyrano[2,3-e ]isoindol-2-one ring system, an heteroanalogue of angelicin, is reported. Our synthetic approach consists of the annelation of the pyran ring on the isoindole moiety using 5-dialkylamino- or 5-hydroxymethylene intermediates as building blocks. The photoantiproliferative activity of the new derivatives was studied. Some of them bearing the benzyl group at the 8 position were active with IC50 in the micromolar range. Cell cytotoxicity involves apoptosis, alteration of cell cycle profile and membrane photodamage.
Lingua originaleEnglish
pagine (da-a)1711-1714
Numero di pagine4
RivistaBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume19
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1313???
  • ???subjectarea.asjc.1300.1312???
  • ???subjectarea.asjc.3000.3003???
  • ???subjectarea.asjc.3000.3002???
  • ???subjectarea.asjc.1300.1308???
  • ???subjectarea.asjc.1600.1605???

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