PTP1B phosphatase as a novel target of oleuropein activity in MCF-7 breast cancer model

Fabrizio Lo Celso; Giampaolo Barone; Giosue' Lo Bosco; Agnieszka Daca; Alicja Kuban-Jankowska; Roksana Wyszkowska; Magdalena Gorska-Ponikowska; Paulina Przychodzen; Tomasz Kostrzewa; Anna Kamm; Magdalena Gorska-Ponikowska; Giosuè Lo Bosco; Giosuè Lo Bosco

PTP1B phosphatase as a novel target of oleuropein activity in MCF-7 breast cancer model

Fabrizio Lo Celso, Giampaolo Barone, Giosue' Lo Bosco, Agnieszka Daca, Alicja Kuban-Jankowska, Roksana Wyszkowska, Magdalena Gorska-Ponikowska, Paulina Przychodzen, Tomasz Kostrzewa, Anna Kamm, Magdalena Gorska-Ponikowska, Giosuè Lo Bosco, Giosuè Lo Bosco

Risultato della ricerca: Article › peer review

4 Citazioni (Scopus)

Abstract

Phosphatase PTP1B has become a therapeutic target for the treatment of type 2-diabetes, whereas recent studies have revealed that PTP1B plays a pivotal role in pathophysiology and development of breast cancer. Oleuropein is a natural, phenolic compound with anticancer activity. The aim of this study was to address the question whether PTP1B constitutes a target for oleuropein in breast cancer MCF-7 cells. The cellular MCF-7 breast cancer model was used in the study. The experiments were performed using cellular viability tests, Elisa assays, immunoprecipitation, flow cytometry analyses and computer modelling. Herein, we evidenced that the reduced activity of phosphatase PTP1B after treatment with oleuropein is strictly correlated with decreased MCF-7 cellular viability and cell cycle arrest. These results provide new insight into further research on oleuropein and possible role of the compound in adjuvant treatment of breast cancer

Lingua originale	English
pagine (da-a)	1-9
Numero di pagine	9
Rivista	Toxicology in Vitro
Volume	61
Stato di pubblicazione	Published - 2019

All Science Journal Classification (ASJC) codes

Toxicology

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PTP1B phosphatase as a novel target of oleuropein activity in MCF-7 breast cancer model. / Lo Celso, Fabrizio ; Barone, Giampaolo ; Lo Bosco, Giosue'; Daca, Agnieszka; Kuban-Jankowska, Alicja; Wyszkowska, Roksana; Gorska-Ponikowska, Magdalena; Przychodzen, Paulina; Kostrzewa, Tomasz; Kamm, Anna; Gorska-Ponikowska, Magdalena; Lo Bosco, Giosuè; Bosco, Giosuè Lo.

In: Toxicology in Vitro, Vol. 61, 2019, pag. 1-9.

Risultato della ricerca: Article › peer review

Lo Celso, Fabrizio ; Barone, Giampaolo ; Lo Bosco, Giosue' ; Daca, Agnieszka ; Kuban-Jankowska, Alicja ; Wyszkowska, Roksana ; Gorska-Ponikowska, Magdalena ; Przychodzen, Paulina ; Kostrzewa, Tomasz ; Kamm, Anna ; Gorska-Ponikowska, Magdalena ; Lo Bosco, Giosuè ; Bosco, Giosuè Lo. / PTP1B phosphatase as a novel target of oleuropein activity in MCF-7 breast cancer model. In: Toxicology in Vitro. 2019 ; Vol. 61. pagg. 1-9.

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title = "PTP1B phosphatase as a novel target of oleuropein activity in MCF-7 breast cancer model",

abstract = "Phosphatase PTP1B has become a therapeutic target for the treatment of type 2-diabetes, whereas recent studies have revealed that PTP1B plays a pivotal role in pathophysiology and development of breast cancer. Oleuropein is a natural, phenolic compound with anticancer activity. The aim of this study was to address the question whether PTP1B constitutes a target for oleuropein in breast cancer MCF-7 cells. The cellular MCF-7 breast cancer model was used in the study. The experiments were performed using cellular viability tests, Elisa assays, immunoprecipitation, flow cytometry analyses and computer modelling. Herein, we evidenced that the reduced activity of phosphatase PTP1B after treatment with oleuropein is strictly correlated with decreased MCF-7 cellular viability and cell cycle arrest. These results provide new insight into further research on oleuropein and possible role of the compound in adjuvant treatment of breast cancer",

author = "{Lo Celso}, Fabrizio and Giampaolo Barone and {Lo Bosco}, Giosue' and Agnieszka Daca and Alicja Kuban-Jankowska and Roksana Wyszkowska and Magdalena Gorska-Ponikowska and Paulina Przychodzen and Tomasz Kostrzewa and Anna Kamm and Magdalena Gorska-Ponikowska and {Lo Bosco}, Giosu{\`e} and Bosco, {Giosu{\`e} Lo}",

year = "2019",

language = "English",

volume = "61",

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journal = "Toxicology in Vitro",

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T1 - PTP1B phosphatase as a novel target of oleuropein activity in MCF-7 breast cancer model

AU - Lo Celso, Fabrizio

AU - Barone, Giampaolo

AU - Lo Bosco, Giosue'

AU - Daca, Agnieszka

AU - Kuban-Jankowska, Alicja

AU - Wyszkowska, Roksana

AU - Gorska-Ponikowska, Magdalena

AU - Przychodzen, Paulina

AU - Kostrzewa, Tomasz

AU - Kamm, Anna

AU - Gorska-Ponikowska, Magdalena

AU - Lo Bosco, Giosuè

AU - Bosco, Giosuè Lo

PY - 2019

Y1 - 2019

N2 - Phosphatase PTP1B has become a therapeutic target for the treatment of type 2-diabetes, whereas recent studies have revealed that PTP1B plays a pivotal role in pathophysiology and development of breast cancer. Oleuropein is a natural, phenolic compound with anticancer activity. The aim of this study was to address the question whether PTP1B constitutes a target for oleuropein in breast cancer MCF-7 cells. The cellular MCF-7 breast cancer model was used in the study. The experiments were performed using cellular viability tests, Elisa assays, immunoprecipitation, flow cytometry analyses and computer modelling. Herein, we evidenced that the reduced activity of phosphatase PTP1B after treatment with oleuropein is strictly correlated with decreased MCF-7 cellular viability and cell cycle arrest. These results provide new insight into further research on oleuropein and possible role of the compound in adjuvant treatment of breast cancer

AB - Phosphatase PTP1B has become a therapeutic target for the treatment of type 2-diabetes, whereas recent studies have revealed that PTP1B plays a pivotal role in pathophysiology and development of breast cancer. Oleuropein is a natural, phenolic compound with anticancer activity. The aim of this study was to address the question whether PTP1B constitutes a target for oleuropein in breast cancer MCF-7 cells. The cellular MCF-7 breast cancer model was used in the study. The experiments were performed using cellular viability tests, Elisa assays, immunoprecipitation, flow cytometry analyses and computer modelling. Herein, we evidenced that the reduced activity of phosphatase PTP1B after treatment with oleuropein is strictly correlated with decreased MCF-7 cellular viability and cell cycle arrest. These results provide new insight into further research on oleuropein and possible role of the compound in adjuvant treatment of breast cancer

UR - http://hdl.handle.net/10447/367184

M3 - Article

VL - 61

SP - 1

EP - 9

JO - Toxicology in Vitro

JF - Toxicology in Vitro

SN - 0887-2333

ER -