Pt(II) complex @mesoporous silica: preparation, characterization and study of release

Risultato della ricerca: Articlepeer review

Abstract

Cisplatin analogs, having cytotoxic activity higher than that exerted by cisplatin, have recently triggered considerable interest by thecommunity. The cis-[PtCl2(DMSO)HL]·2DMSO, where HL = 7-amino-2-(methylthio)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylicacid, has shown a potent cytotoxic activity on HepG2 hepatocarcinoma cells, while under identical conditions, it did not affect normalimmortalized human liver cells (Chang). In this work, the above complex has been incorporated into MCM41 mesoporous silica, pureand functionalized with amino group, which is considered one of the best host for a drug delivery system for carrying high dosages of avariety of drugs in their mesopores. Since the controlled release of an anticancer drug helps to maintain its therapeutic level for anextended time period while minimizing undesirable high peaks immediately following administration, the in vitro tests have beenperformed in order to obtain the corresponding drug release profile. The investigated system demonstrated to be an efficient system forpharmaceutic controlled release. A deepened characterization of the systems has been performed in order to known their structure andfeatures and to speculate the mechanisms involved in the release.
Lingua originaleEnglish
pagine (da-a)1621-1626
Numero di pagine6
RivistaBiointerface Research in Applied Chemistry
Volume6
Stato di pubblicazionePublished - 2016

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