Psychological profile and unexpected pain in oral lichen planus: a case-control multicenter SIPMO study

Vera Panzarella, Giuseppina Campisi, Luca Guarda Nardini, Davide Gissi, Massimo Aria, Gianluca Tenore, Elena M. Varoni, Alessio Gambino, Margherita Gobbo, Rosario Serpico, Marco Ardore, Lorenzo Azzi, Alessandra Majorana, Lucio Montebugnoli, Fabio Croveri, Giuseppe Colella, Marco Nisi, Marco Cabras, Michele Giuliani, Gioele GiocoElena Calabria, Alessandro Antonelli, Mario Gabriele, Lorenzo Lo Muzio, Ciro Emiliano Boschetti, Noemi Coppola, Maria Eleonora Bizzoca, Sonia Marino, Spadari Francesco, Monica Pentenero, Umberto Romeo, Carlo Lajolo, Elena Bardellini, Matteo Biasotto, Daniela Adamo, Andrea Sardella, Amerigo Giudice, Michele Davide Mignogna, Paolo Vescovi, Giovanni Lodi

Risultato della ricerca: Articlepeer review

Abstract

OBJECTIVES: To analyze psychological profiles, pain and oral symptoms in patients with oral lichen planus (OLP).MATERIALS AND METHODS: 300 patients with keratotic OLP (K-OLP; reticular, papular, plaque-like subtypes), 300 patients with predominant non-keratotic OLP (nK-OLP; erythematosus atrophic, erosive, ulcerative, bullous subtypes) and 300 controls were recruited in 15 universities. The number of oral sites involved and oral symptoms were recorded. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were administered.RESULTS: The OLP patients, especially the nK-OLP, showed higher scores in the NRS, T-PRI, HAM-D, HAM-A and PSQI compared with the controls (p-value<.001** ). A positive correlation between the NRS, T-PRI, HAM-A, HAM-D and PSQI was found with the number of oral symptoms and number of oral sites involved. Pain was reported in 67.3 % of nK-OLP and 49.7% of K-OLP cases with poor correspondence between the site of lesions and the site of the symptoms.CONCLUSIONS: Mood disorders are frequently associated with OLP with an unexpected symptomatology correlated with the number of oral symptoms and with the extension of disease suggesting a peripheral neuropathy.
Lingua originaleEnglish
Numero di pagine43
RivistaOral Diseases
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.3500.3500???

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