Protocol of a multicenter international randomized controlled manikin study on different protocols of cardiopulmonary resuscitation for laypeople (MANI-CPR)

Andrea Cortegiani, Pasquale Iozzo, Sandrine Dénéréaz, Ottavia Eleonora Ferraro, Enrico Baldi, Daniele Bertaia, Enrico Contri, Paola Borrelli, Roman Burkart, Alberto Somaschini, Stefano Cornara, Michela Tonani, Yves Dénéréaz, Michael Terrapon, Christian Tami, Susi Boldarin, Caroline Tinguely, Amedeo Cutuli, Cinzia Cereda, Daniel Lopez & 1 others Claudio Deiuri

Risultato della ricerca: Article

1 Citazione (Scopus)

Abstract

Introduction Out-of-hospital cardiac arrest is one of the leading causes of death in industrialised countries. Survival depends on prompt identification of cardiac arrest and on the quality and timing of cardiopulmonary resuscitation (CPR) and defibrillation. For laypeople, there has been a growing interest on hands-only CPR, meaning continuous chest compression without interruption to perform ventilations. It has been demonstrated that intentional interruptions in hands-only CPR can increase its quality. The aim of this randomised trial is to compare three CPR protocols performed with different intentional interruptions with hands-only CPR. Methods and analysis This is a prospective randomised trial performed in eight training centres. Laypeople who passed a basic life support course will be randomised to one of the four CPR protocols in an 8 min simulated cardiac arrest scenario on a manikin: (1) 30 compressions and 2 s pause; (2) 50 compressions and 5 s pause; (3) 100 compressions and 10 s pause; (4) hands-only. The calculated sample size is 552 people. The primary outcome is the percentage of chest compression performed with correct depth evaluated by a computerised feedback system (Laerdal QCPR). Ethics and dissemination . Due to the nature of the study, we obtained a waiver from the Ethics Committee (IRCCS Policlinico San Matteo, Pavia, Italy). All participants will sign an informed consent form before randomisation. The results of this study will be published in peer-reviewed journal. The data collected will also be made available in a public data repository. trial registration number NCT02632500.
Lingua originaleEnglish
pagine (da-a)e019723-
Numero di pagine6
RivistaBMJ Open
Volume8
Stato di pubblicazionePublished - 2018

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Manikins
Cardiopulmonary Resuscitation
Hand
Heart Arrest
Thorax
Consent Forms
Out-of-Hospital Cardiac Arrest
Ethics Committees
Random Allocation
Developed Countries
Ethics
Sample Size
Italy
Ventilation
Cause of Death

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Protocol of a multicenter international randomized controlled manikin study on different protocols of cardiopulmonary resuscitation for laypeople (MANI-CPR). / Cortegiani, Andrea; Iozzo, Pasquale; Dénéréaz, Sandrine; Ferraro, Ottavia Eleonora; Baldi, Enrico; Bertaia, Daniele; Contri, Enrico; Borrelli, Paola; Burkart, Roman; Somaschini, Alberto; Cornara, Stefano; Tonani, Michela; Dénéréaz, Yves; Terrapon, Michael; Tami, Christian; Boldarin, Susi; Tinguely, Caroline; Cutuli, Amedeo; Cereda, Cinzia; Lopez, Daniel; Deiuri, Claudio.

In: BMJ Open, Vol. 8, 2018, pag. e019723-.

Risultato della ricerca: Article

Cortegiani, A, Iozzo, P, Dénéréaz, S, Ferraro, OE, Baldi, E, Bertaia, D, Contri, E, Borrelli, P, Burkart, R, Somaschini, A, Cornara, S, Tonani, M, Dénéréaz, Y, Terrapon, M, Tami, C, Boldarin, S, Tinguely, C, Cutuli, A, Cereda, C, Lopez, D & Deiuri, C 2018, 'Protocol of a multicenter international randomized controlled manikin study on different protocols of cardiopulmonary resuscitation for laypeople (MANI-CPR)', BMJ Open, vol. 8, pagg. e019723-.
Cortegiani, Andrea ; Iozzo, Pasquale ; Dénéréaz, Sandrine ; Ferraro, Ottavia Eleonora ; Baldi, Enrico ; Bertaia, Daniele ; Contri, Enrico ; Borrelli, Paola ; Burkart, Roman ; Somaschini, Alberto ; Cornara, Stefano ; Tonani, Michela ; Dénéréaz, Yves ; Terrapon, Michael ; Tami, Christian ; Boldarin, Susi ; Tinguely, Caroline ; Cutuli, Amedeo ; Cereda, Cinzia ; Lopez, Daniel ; Deiuri, Claudio. / Protocol of a multicenter international randomized controlled manikin study on different protocols of cardiopulmonary resuscitation for laypeople (MANI-CPR). In: BMJ Open. 2018 ; Vol. 8. pagg. e019723-.
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abstract = "Introduction Out-of-hospital cardiac arrest is one of the leading causes of death in industrialised countries. Survival depends on prompt identification of cardiac arrest and on the quality and timing of cardiopulmonary resuscitation (CPR) and defibrillation. For laypeople, there has been a growing interest on hands-only CPR, meaning continuous chest compression without interruption to perform ventilations. It has been demonstrated that intentional interruptions in hands-only CPR can increase its quality. The aim of this randomised trial is to compare three CPR protocols performed with different intentional interruptions with hands-only CPR. Methods and analysis This is a prospective randomised trial performed in eight training centres. Laypeople who passed a basic life support course will be randomised to one of the four CPR protocols in an 8 min simulated cardiac arrest scenario on a manikin: (1) 30 compressions and 2 s pause; (2) 50 compressions and 5 s pause; (3) 100 compressions and 10 s pause; (4) hands-only. The calculated sample size is 552 people. The primary outcome is the percentage of chest compression performed with correct depth evaluated by a computerised feedback system (Laerdal QCPR). Ethics and dissemination . Due to the nature of the study, we obtained a waiver from the Ethics Committee (IRCCS Policlinico San Matteo, Pavia, Italy). All participants will sign an informed consent form before randomisation. The results of this study will be published in peer-reviewed journal. The data collected will also be made available in a public data repository. trial registration number NCT02632500.",
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T1 - Protocol of a multicenter international randomized controlled manikin study on different protocols of cardiopulmonary resuscitation for laypeople (MANI-CPR)

AU - Cortegiani, Andrea

AU - Iozzo, Pasquale

AU - Dénéréaz, Sandrine

AU - Ferraro, Ottavia Eleonora

AU - Baldi, Enrico

AU - Bertaia, Daniele

AU - Contri, Enrico

AU - Borrelli, Paola

AU - Burkart, Roman

AU - Somaschini, Alberto

AU - Cornara, Stefano

AU - Tonani, Michela

AU - Dénéréaz, Yves

AU - Terrapon, Michael

AU - Tami, Christian

AU - Boldarin, Susi

AU - Tinguely, Caroline

AU - Cutuli, Amedeo

AU - Cereda, Cinzia

AU - Lopez, Daniel

AU - Deiuri, Claudio

PY - 2018

Y1 - 2018

N2 - Introduction Out-of-hospital cardiac arrest is one of the leading causes of death in industrialised countries. Survival depends on prompt identification of cardiac arrest and on the quality and timing of cardiopulmonary resuscitation (CPR) and defibrillation. For laypeople, there has been a growing interest on hands-only CPR, meaning continuous chest compression without interruption to perform ventilations. It has been demonstrated that intentional interruptions in hands-only CPR can increase its quality. The aim of this randomised trial is to compare three CPR protocols performed with different intentional interruptions with hands-only CPR. Methods and analysis This is a prospective randomised trial performed in eight training centres. Laypeople who passed a basic life support course will be randomised to one of the four CPR protocols in an 8 min simulated cardiac arrest scenario on a manikin: (1) 30 compressions and 2 s pause; (2) 50 compressions and 5 s pause; (3) 100 compressions and 10 s pause; (4) hands-only. The calculated sample size is 552 people. The primary outcome is the percentage of chest compression performed with correct depth evaluated by a computerised feedback system (Laerdal QCPR). Ethics and dissemination . Due to the nature of the study, we obtained a waiver from the Ethics Committee (IRCCS Policlinico San Matteo, Pavia, Italy). All participants will sign an informed consent form before randomisation. The results of this study will be published in peer-reviewed journal. The data collected will also be made available in a public data repository. trial registration number NCT02632500.

AB - Introduction Out-of-hospital cardiac arrest is one of the leading causes of death in industrialised countries. Survival depends on prompt identification of cardiac arrest and on the quality and timing of cardiopulmonary resuscitation (CPR) and defibrillation. For laypeople, there has been a growing interest on hands-only CPR, meaning continuous chest compression without interruption to perform ventilations. It has been demonstrated that intentional interruptions in hands-only CPR can increase its quality. The aim of this randomised trial is to compare three CPR protocols performed with different intentional interruptions with hands-only CPR. Methods and analysis This is a prospective randomised trial performed in eight training centres. Laypeople who passed a basic life support course will be randomised to one of the four CPR protocols in an 8 min simulated cardiac arrest scenario on a manikin: (1) 30 compressions and 2 s pause; (2) 50 compressions and 5 s pause; (3) 100 compressions and 10 s pause; (4) hands-only. The calculated sample size is 552 people. The primary outcome is the percentage of chest compression performed with correct depth evaluated by a computerised feedback system (Laerdal QCPR). Ethics and dissemination . Due to the nature of the study, we obtained a waiver from the Ethics Committee (IRCCS Policlinico San Matteo, Pavia, Italy). All participants will sign an informed consent form before randomisation. The results of this study will be published in peer-reviewed journal. The data collected will also be made available in a public data repository. trial registration number NCT02632500.

UR - http://hdl.handle.net/10447/289818

UR - http://bmjopen.bmj.com/content/early/by/section

M3 - Article

VL - 8

SP - e019723-

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

ER -