Purpose: Oxidative stress plays a pivotal role in the pathogenesis of the metabolic syndromeand in the progression of its complications. Carbonylated proteins are a stablemarker of severe oxidative stress because damage to the protein structure is irreversible andmay cause an inhibition of their enzymatic activity or an increased susceptibility to proteolysis. ere are few data regarding protein oxidation in metabolic syndrome, althoughelevated levels of carbonyl groups are o en detected in subjects with obesity, diabetes mellitus,hypertension or dyslipidemia, well-known components of the metaboic syndrome. Inparticular, obesity, insulin resistance and diabetes mellitus are frequently associated withincreased protein carbonylation. A relationship between insulin resistance, protein oxidativestress and in ammation has also been suggested as well as protein oxidation productsare correlated with overexpression of resistin, TNF-α and IL-6.Conclusion: erapeutic interventions based on lifestyle modi cations and pharmacologicalagents in order to correct all the main risk factors in uence oxidative stress and proteincarbonylation.
|Numero di pagine||8|
|Rivista||CLINICAL AND INVESTIGATIVE MEDICINE-MEDECINE CLINIQUE ET EXPERIMENTALE|
|Stato di pubblicazione||Published - 2013|
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