Prospective sonographic detection of spina bifida at 11-14 weeks and systematic literature review

Gaspare Cucinella, Antonino Perino, Emanuela Orlandi, Francesco Orlandi, Cinzia Rossi, Cinzia Rossi

Risultato della ricerca: Articlepeer review

17 Citazioni (Scopus)


Objective: To conduct a literature review to assess the effectiveness of first trimesterultrasonographic markers of spina bifida (SB) integrating data with our prospective experience.Methods: The analysis of the SB cases that we prospectively detected in the first trimester,between January 2012 and February 2014, and a systematic review of all the papers evaluatingthe effectiveness of SB ultrasonographic markers at 11–14 weeks, namely brain stem diameter(BS), fourth ventricle/intracranial translucency (IT), cisterna magna (CM), brain stem/occipitalbone distance (BSOB), the ratio between BS and BSOB. Some studies assess only theeffectiveness of IT, others include more parameters, and few include them all.Results: We prospectively detected four SB cases, three open (OSB) and one closed (CSB), in alow risk population undergoing first trimester screening. In the three OSB, CM (in 2/3 cases) andBSOB (3/3) distance were below the 5th percentile, BS and BS/BSOB ratio (3/3) were above the95th percentile. In the CSB, all the measurements were within normal limits.Conclusion: The literature and our data agree that most fetuses with OSB demonstrate in thefirst trimester positive sonographic markers in the posterior fossa, but additional prospectivestudies are needed to establish the best protocol for OSB screening.
Lingua originaleEnglish
Numero di pagine5
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

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