Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 397-402 |
| Numero di pagine | 6 |
| Rivista | International Journal of Infectious Diseases |
| Volume | 16 |
| Stato di pubblicazione | Published - 2012 |
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All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Infectious Diseases
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Prospective evaluation of hepatic steatosis in HIV-infected patients with orwithout hepatitis C virus co-infection. / Di Carlo, Paola; Terranova, Antonino; Giannitrapani, Lydia; Soresi, Maurizio; Montalto, Giuseppe; Li Vecchi, Valentina.
In: International Journal of Infectious Diseases, Vol. 16, 2012, pag. 397-402.Risultato della ricerca: Article
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TY - JOUR
T1 - Prospective evaluation of hepatic steatosis in HIV-infected patients with orwithout hepatitis C virus co-infection
AU - Di Carlo, Paola
AU - Terranova, Antonino
AU - Giannitrapani, Lydia
AU - Soresi, Maurizio
AU - Montalto, Giuseppe
AU - Li Vecchi, Valentina
PY - 2012
Y1 - 2012
N2 - Background: Limited data are available on hepatic steatosis (HS) in HIV patients who are not infectedwith hepatitis C virus (HCV). The aims of this study were to assess the prevalence of HS and its risk factorsin HIV patients with and without HCV infection, and to evaluate whether HS correlates with advancedliver fibrosis and/or cardiovascular disease risk.Methods: Fifty-seven HIV mono-infected and 61 HIV/HCV co-infected patients were enrolledconsecutively. All patients underwent liver ultrasound and transient elastography. The main parametersof liver function, HIV and HCV viral loads, CD4+ cell counts, and data on highly active antiretroviraltherapy (HAART) were recorded. Cardiovascular disease risk was evaluated using the 10-yearFramingham risk score.Results: HS prevalence in the whole HIV population was 53% (54% in mono-infected patients and 51% inco-infected patients). HS was associated with lipodystrophy and triglyceride values (p < 0.0001),metabolic syndrome (p < 0.0004), and total cholesterol levels (p < 0.001) in both HIV groups. In HIVmono-infected patients, HS was linked with HAART exposure of >1 year (p < 0.01). By multivariateanalysis, only triglyceride levels (p < 0.02) and Framingham risk score (p < 0.05) were independentlyassociated with HS in both HIV groups. No correlation was observed between HS and advanced liverfibrosis, measured by transient elastography.Conclusions: HS was common in HIV patients, occurring in about half of the population. HS was found tobe linked with the Framingham risk score, but was not correlated with advanced liver fibrosis. Wesuggest that in our HIV population with HS, the burden of cardiovascular disease risk is greater than thatof liver disease progression.
AB - Background: Limited data are available on hepatic steatosis (HS) in HIV patients who are not infectedwith hepatitis C virus (HCV). The aims of this study were to assess the prevalence of HS and its risk factorsin HIV patients with and without HCV infection, and to evaluate whether HS correlates with advancedliver fibrosis and/or cardiovascular disease risk.Methods: Fifty-seven HIV mono-infected and 61 HIV/HCV co-infected patients were enrolledconsecutively. All patients underwent liver ultrasound and transient elastography. The main parametersof liver function, HIV and HCV viral loads, CD4+ cell counts, and data on highly active antiretroviraltherapy (HAART) were recorded. Cardiovascular disease risk was evaluated using the 10-yearFramingham risk score.Results: HS prevalence in the whole HIV population was 53% (54% in mono-infected patients and 51% inco-infected patients). HS was associated with lipodystrophy and triglyceride values (p < 0.0001),metabolic syndrome (p < 0.0004), and total cholesterol levels (p < 0.001) in both HIV groups. In HIVmono-infected patients, HS was linked with HAART exposure of >1 year (p < 0.01). By multivariateanalysis, only triglyceride levels (p < 0.02) and Framingham risk score (p < 0.05) were independentlyassociated with HS in both HIV groups. No correlation was observed between HS and advanced liverfibrosis, measured by transient elastography.Conclusions: HS was common in HIV patients, occurring in about half of the population. HS was found tobe linked with the Framingham risk score, but was not correlated with advanced liver fibrosis. Wesuggest that in our HIV population with HS, the burden of cardiovascular disease risk is greater than thatof liver disease progression.
KW - Steatosis HIV HIV/HCV co-infected Non-alcoholic fatty liver disease Liver disease Antiretroviral medication Metabolic syndrome Lipodystrophy
UR - http://hdl.handle.net/10447/62820
M3 - Article
VL - 16
SP - 397
EP - 402
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
SN - 1201-9712
ER -