Prospective associations of cardiovascular disease with physical performance and disability: A longitudinal cohort study in the Osteoarthritis Initiative

Nicola Veronese, Mike Loosemore, Alberto Cester, Pinar Soysal, Francesco Bolzetta, Nicola Veronese, Lee Smith, Guillermo F. López-Sánchez, Jacopo Demurtas, Sarah E Jackson, Ai Koyanagi, Stefania Maggi, Brendon Stubbs, Vania Noventa

Risultato della ricerca: Articlepeer review

Abstract

Background: Literature regarding cardiovascular disease (CVD) and incident physical performance limitations and disability in older people is equivocal. Aims: This study aimed to investigate whether CVD is longitudinally associated with incident physical performance limitations and disability in a large population-based sample. Methods: This was an 8‑year prospective study using data collected as part of the Osteoarthritis Initiative. Participants were community-dwelling adults with knee osteoarthritis or at high risk for this condition. Diagnosed CVD was self-reported. Physical performance was assessed with measures of chair stand time and gait speed, whereas disability was assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Longitudinal associations between CVD and changes in physical performance tests (chair stand time and gait speed) and disability score were analyzed using generalized linear models with repeated measurements. Results: The analyzed sample comprised 4796 adults (mean age 61.2 years, 58.5% female), of whom 313 people (6.5%) reported CVD at baseline. During 8 years of follow-up, after adjustment for 11 potential confounders measured at baseline, those with CVD experienced a worse profile in chair stand time over the 8‑year follow-up period than those without CVD (p = 0.006). Conclusion: In a cohort of middle-aged and older adults with knee osteoarthritis or at high risk for this condition those with CVD experienced a worse profile in chair stand time over the 8‑year follow-up period than those without CVD; however, CVD was not significantly associated with an increased incidence of poor gait speed and disability over 8 years of follow-up. Importantly, no associations were observed when utilizing propensity score matching. © 2019, Springer-Verlag GmbH Austria, part of Springer Nature.
Lingua originaleEnglish
pagine (da-a)73-78
Numero di pagine6
RivistaWIENER KLINISCHE WOCHENSCHRIFT. EDUCATION
Volume132
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

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