Prognostic value of HSP27 in head and neck squamous cell carcinoma: a retrospective analysis of 57 tumours.

Giuseppina Campisi, Stefania Stalbano, Rosalia Leonardi, Silvia Falaschini, Lorenzo Lo Muzio, Lorenzo Lo Muzio, Corrado Rubini, Francesco Carinci, Gaetano De Rosa, Antonio Farina, Francesca Ferrari

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30 Citazioni (Scopus)

Abstract

Background: The aims of the present study were toassess the prevalence of HSP27 expression in oral squamous cellcarcinoma (OSCC) and to verify whether HSP27 can beconsidered to be a marker of prognosis in patients with OSCC.Materials and Methods: The immunohistochemical expression ofHSP27 was evaluated in 57 OSCC, who received standardtreatment and monitoring. After grouping for HSP27 expression,OSCCs were statistically analysed for the variables age, gender,histological grading, TNM, staging and survival rate. Univariateand multivariate analyses were performed. Results: HSP27 wasfound to be reduced in 31 OSCC and was normally expressed in26 OSCC. The pattern and intensity of HSP27 immunolabellingdid not show significant differences in relation to any variablesretrospectively considered. In terms of prognostic significance,HSP27 reduced expression was found to have an independentassociation with the poorest overall survival rate (p=0.009;OR= 4.404; CI=1.444:13.427 by Cox regression). Conclusion:HSP27 reduced expression is an early marker of poor prognosis,useful in identifying aggressive biological behaviour in OSCCcases even before relapse
Lingua originaleEnglish
pagine (da-a)1343-1349
Numero di pagine7
RivistaAnticancer Research
Volume26
Stato di pubblicazionePublished - 2006

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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