PROGNOSTIC VALUE OF ESTIMATED GLOMERULAR FILTRATION RATE IN HOSPITALIZED ELDERLY PATIENTS

Mario Barbagallo, Ligia Juliana Dominguez Rodriguez, Salvatore Corrao, Emma Riva, Luca Pasina, Carlotta Franchi, Pier Mannuccio Mannucci, Codjo Djignefa Djade, Sara Mandelli, Laura De La Higuera, Maura Marcucci, Luca Pasina, Alessandra Marengoni, Mauro Tettamanti, Francesco Salerno, Alessandro Nobili

Risultato della ricerca: Article

9 Citazioni (Scopus)

Abstract

A multicenter observational study, REPOSI (REgustri POliterapie Società Italiana di Medicina Interna), was conducted to assess the prognostic value of glomerular filtration rate (eGFR) on in-hospital mortality, hospital readmission and death within 3 months, in a sample of elderly patients (n=1,363) admitted to 66 internal medicine and geriatric wards. Bases on eGFR, calculated by the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, subjects at hostpital admission were classified into three groups: group 1 with normal eGFR (60 ml/min/1.73m2, reference group), group 2 with moderately reduced eGFR (30-59 ml/min/1.73 m2) and group 3 with severely reduced eGFR (<30 ml/min/1.73 m2). Patients with the lowest eGFR (group 3) on admission were more likely to be older, to have a greater cognitive and functional impairment and a high rate of comorbidities. Multivariable logistic regression analysis showed that severely reduced eGFR at the time of admission was associated with in-hospital mortality (OR 3.00; 95 % CI 1.20-7.39, p=0.0230), but not with re-hospitalization (OR 0.97; 95% CI 0.54-1.76, p=0.9156) or mortality at 3 months after discharge (OR 1.93; 95 % CI 0.92-4.04, p=0.1582). On the contrary, an increased risk (OR 2.60; 95 % CI 1.13-5.98, p=0.0813) to die within 3 months after discharge was associated with decreased eGFR measured at the time of discharge. Our study demonstrates that severely reduced eGFRs in elderly patients admitted to hospital are strong predictors of the risk of dying during hospitalization, and that this measurement at the time of discharge helps to predict early death after hospitalization.
Lingua originaleEnglish
pagine (da-a)735-747
Numero di pagine13
RivistaINTERNAL AND EMERGENCY MEDICINE
Volume9
Stato di pubblicazionePublished - 2013

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Glomerular Filtration Rate
Hospitalization
Hospital Mortality
Patient Readmission
Internal Medicine
Chronic Renal Insufficiency
Geriatrics
Multicenter Studies
Observational Studies
Comorbidity
Epidemiology
Logistic Models
Regression Analysis
Mortality

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Emergency Medicine

Cita questo

PROGNOSTIC VALUE OF ESTIMATED GLOMERULAR FILTRATION RATE IN HOSPITALIZED ELDERLY PATIENTS. / Barbagallo, Mario; Dominguez Rodriguez, Ligia Juliana; Corrao, Salvatore; Riva, Emma; Pasina, Luca; Franchi, Carlotta; Mannucci, Pier Mannuccio; Djade, Codjo Djignefa; Mandelli, Sara; De La Higuera, Laura; Marcucci, Maura; Pasina, Luca; Marengoni, Alessandra; Tettamanti, Mauro; Salerno, Francesco; Nobili, Alessandro.

In: INTERNAL AND EMERGENCY MEDICINE, Vol. 9, 2013, pag. 735-747.

Risultato della ricerca: Article

Barbagallo, M, Dominguez Rodriguez, LJ, Corrao, S, Riva, E, Pasina, L, Franchi, C, Mannucci, PM, Djade, CD, Mandelli, S, De La Higuera, L, Marcucci, M, Pasina, L, Marengoni, A, Tettamanti, M, Salerno, F & Nobili, A 2013, 'PROGNOSTIC VALUE OF ESTIMATED GLOMERULAR FILTRATION RATE IN HOSPITALIZED ELDERLY PATIENTS', INTERNAL AND EMERGENCY MEDICINE, vol. 9, pagg. 735-747.
Barbagallo, Mario ; Dominguez Rodriguez, Ligia Juliana ; Corrao, Salvatore ; Riva, Emma ; Pasina, Luca ; Franchi, Carlotta ; Mannucci, Pier Mannuccio ; Djade, Codjo Djignefa ; Mandelli, Sara ; De La Higuera, Laura ; Marcucci, Maura ; Pasina, Luca ; Marengoni, Alessandra ; Tettamanti, Mauro ; Salerno, Francesco ; Nobili, Alessandro. / PROGNOSTIC VALUE OF ESTIMATED GLOMERULAR FILTRATION RATE IN HOSPITALIZED ELDERLY PATIENTS. In: INTERNAL AND EMERGENCY MEDICINE. 2013 ; Vol. 9. pagg. 735-747.
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title = "PROGNOSTIC VALUE OF ESTIMATED GLOMERULAR FILTRATION RATE IN HOSPITALIZED ELDERLY PATIENTS",
abstract = "A multicenter observational study, REPOSI (REgustri POliterapie Societ{\`a} Italiana di Medicina Interna), was conducted to assess the prognostic value of glomerular filtration rate (eGFR) on in-hospital mortality, hospital readmission and death within 3 months, in a sample of elderly patients (n=1,363) admitted to 66 internal medicine and geriatric wards. Bases on eGFR, calculated by the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, subjects at hostpital admission were classified into three groups: group 1 with normal eGFR (60 ml/min/1.73m2, reference group), group 2 with moderately reduced eGFR (30-59 ml/min/1.73 m2) and group 3 with severely reduced eGFR (<30 ml/min/1.73 m2). Patients with the lowest eGFR (group 3) on admission were more likely to be older, to have a greater cognitive and functional impairment and a high rate of comorbidities. Multivariable logistic regression analysis showed that severely reduced eGFR at the time of admission was associated with in-hospital mortality (OR 3.00; 95 {\%} CI 1.20-7.39, p=0.0230), but not with re-hospitalization (OR 0.97; 95{\%} CI 0.54-1.76, p=0.9156) or mortality at 3 months after discharge (OR 1.93; 95 {\%} CI 0.92-4.04, p=0.1582). On the contrary, an increased risk (OR 2.60; 95 {\%} CI 1.13-5.98, p=0.0813) to die within 3 months after discharge was associated with decreased eGFR measured at the time of discharge. Our study demonstrates that severely reduced eGFRs in elderly patients admitted to hospital are strong predictors of the risk of dying during hospitalization, and that this measurement at the time of discharge helps to predict early death after hospitalization.",
author = "Mario Barbagallo and {Dominguez Rodriguez}, {Ligia Juliana} and Salvatore Corrao and Emma Riva and Luca Pasina and Carlotta Franchi and Mannucci, {Pier Mannuccio} and Djade, {Codjo Djignefa} and Sara Mandelli and {De La Higuera}, Laura and Maura Marcucci and Luca Pasina and Alessandra Marengoni and Mauro Tettamanti and Francesco Salerno and Alessandro Nobili",
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TY - JOUR

T1 - PROGNOSTIC VALUE OF ESTIMATED GLOMERULAR FILTRATION RATE IN HOSPITALIZED ELDERLY PATIENTS

AU - Barbagallo, Mario

AU - Dominguez Rodriguez, Ligia Juliana

AU - Corrao, Salvatore

AU - Riva, Emma

AU - Pasina, Luca

AU - Franchi, Carlotta

AU - Mannucci, Pier Mannuccio

AU - Djade, Codjo Djignefa

AU - Mandelli, Sara

AU - De La Higuera, Laura

AU - Marcucci, Maura

AU - Pasina, Luca

AU - Marengoni, Alessandra

AU - Tettamanti, Mauro

AU - Salerno, Francesco

AU - Nobili, Alessandro

PY - 2013

Y1 - 2013

N2 - A multicenter observational study, REPOSI (REgustri POliterapie Società Italiana di Medicina Interna), was conducted to assess the prognostic value of glomerular filtration rate (eGFR) on in-hospital mortality, hospital readmission and death within 3 months, in a sample of elderly patients (n=1,363) admitted to 66 internal medicine and geriatric wards. Bases on eGFR, calculated by the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, subjects at hostpital admission were classified into three groups: group 1 with normal eGFR (60 ml/min/1.73m2, reference group), group 2 with moderately reduced eGFR (30-59 ml/min/1.73 m2) and group 3 with severely reduced eGFR (<30 ml/min/1.73 m2). Patients with the lowest eGFR (group 3) on admission were more likely to be older, to have a greater cognitive and functional impairment and a high rate of comorbidities. Multivariable logistic regression analysis showed that severely reduced eGFR at the time of admission was associated with in-hospital mortality (OR 3.00; 95 % CI 1.20-7.39, p=0.0230), but not with re-hospitalization (OR 0.97; 95% CI 0.54-1.76, p=0.9156) or mortality at 3 months after discharge (OR 1.93; 95 % CI 0.92-4.04, p=0.1582). On the contrary, an increased risk (OR 2.60; 95 % CI 1.13-5.98, p=0.0813) to die within 3 months after discharge was associated with decreased eGFR measured at the time of discharge. Our study demonstrates that severely reduced eGFRs in elderly patients admitted to hospital are strong predictors of the risk of dying during hospitalization, and that this measurement at the time of discharge helps to predict early death after hospitalization.

AB - A multicenter observational study, REPOSI (REgustri POliterapie Società Italiana di Medicina Interna), was conducted to assess the prognostic value of glomerular filtration rate (eGFR) on in-hospital mortality, hospital readmission and death within 3 months, in a sample of elderly patients (n=1,363) admitted to 66 internal medicine and geriatric wards. Bases on eGFR, calculated by the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, subjects at hostpital admission were classified into three groups: group 1 with normal eGFR (60 ml/min/1.73m2, reference group), group 2 with moderately reduced eGFR (30-59 ml/min/1.73 m2) and group 3 with severely reduced eGFR (<30 ml/min/1.73 m2). Patients with the lowest eGFR (group 3) on admission were more likely to be older, to have a greater cognitive and functional impairment and a high rate of comorbidities. Multivariable logistic regression analysis showed that severely reduced eGFR at the time of admission was associated with in-hospital mortality (OR 3.00; 95 % CI 1.20-7.39, p=0.0230), but not with re-hospitalization (OR 0.97; 95% CI 0.54-1.76, p=0.9156) or mortality at 3 months after discharge (OR 1.93; 95 % CI 0.92-4.04, p=0.1582). On the contrary, an increased risk (OR 2.60; 95 % CI 1.13-5.98, p=0.0813) to die within 3 months after discharge was associated with decreased eGFR measured at the time of discharge. Our study demonstrates that severely reduced eGFRs in elderly patients admitted to hospital are strong predictors of the risk of dying during hospitalization, and that this measurement at the time of discharge helps to predict early death after hospitalization.

UR - http://hdl.handle.net/10447/225755

M3 - Article

VL - 9

SP - 735

EP - 747

JO - INTERNAL AND EMERGENCY MEDICINE

JF - INTERNAL AND EMERGENCY MEDICINE

SN - 1970-9366

ER -