Prognostic role of aldosterone in patients with acute coronary syndrome: short and medium term follow-up.

Pasquale Assennato, Salvatore Novo, Giuseppina Novo, Valentina Pitruzzella, Egle Corrado, Antonino Mignano, Antonino Rotolo, Pasquale Assennato, Egle Corrado, Valentina Pitruzzella, Salvatore Novo, Antonino Mignano, Giuseppina Novo, Gaspare Arnone, M. Teresa Arnone

Risultato della ricerca: Article

4 Citazioni (Scopus)

Abstract

AIMS: Different studies have shown a correlation between aldosterone, atherosclerosis and ischemia in the past decade. Evidence exists for the relationship between high levels of aldosterone and augmented risk of cardiovascular diseases, such as hypertension, cardiac failure, coronary artery disease and stroke. The objective of this study was to determine the prognostic role of aldosterone in patients with myocardial infarction. METHODS:The study population included 96 consecutive patients admitted to our department for ST-elevated and non-ST-elevated myocardial infarction from June 2009 to March 2012. Plasma aldosterone levels were measured at admission to hospital in all patients. A 2-year prospective follow-up was performed, and fatal events and non-fatal events, such as reinfarction, congestive heart failure and arrhythmias, were recorded. RESULTS:Aldosterone levels at admission were associated with incidence of congestive heart failure (P = 0.02), ventricular arrhythmias (P = 0.01) and all complications (P = 0.003) after 1-month follow-up. Moreover, high aldosterone levels gave important information in the medium term (24 ± 6 months). Specifically, aldosterone was a predictive variable of reinfarction (P < 0.0001), congestive heart failure (P < 0.0001) and adverse events (P = 0.0002). The logistic regression analysis confirmed these results and showed that aldosterone may be predictive of adverse events at medium-term follow-up (odds ratio 1.1, 95% confidence interval 1.03-1.15, P = 0.02). CONCLUSION:These data show a strong and significant correlation between plasma aldosterone levels at admission for myocardial infarction and fatal and nonfatal adverse events. Aldosterone appears to be a main marker of adverse clinical outcome, in accordance with the literature. These data suggest the need to identify whether antialdosteronic drug treatment, applied acutely in patients with aldosterone elevation, can influence favorably the prognosis of patients with myocardial infarction.
Lingua originaleEnglish
pagine (da-a)-
Numero di pagine0
RivistaJournal of Cardiovascular Medicine
Volume0
Stato di pubblicazionePublished - 2013

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Acute Coronary Syndrome
Aldosterone
Heart Failure
Myocardial Infarction
Cardiac Arrhythmias
Coronary Artery Disease
Atherosclerosis
Cardiovascular Diseases
Ischemia
Biomarkers
Logistic Models
Stroke
Odds Ratio
Regression Analysis
Confidence Intervals
Hypertension

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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Prognostic role of aldosterone in patients with acute coronary syndrome: short and medium term follow-up. / Assennato, Pasquale; Novo, Salvatore; Novo, Giuseppina; Pitruzzella, Valentina; Corrado, Egle; Mignano, Antonino; Rotolo, Antonino; Assennato, Pasquale; Corrado, Egle; Pitruzzella, Valentina; Novo, Salvatore; Mignano, Antonino; Novo, Giuseppina; Arnone, Gaspare; Arnone, M. Teresa.

In: Journal of Cardiovascular Medicine, Vol. 0, 2013, pag. -.

Risultato della ricerca: Article

Assennato, Pasquale ; Novo, Salvatore ; Novo, Giuseppina ; Pitruzzella, Valentina ; Corrado, Egle ; Mignano, Antonino ; Rotolo, Antonino ; Assennato, Pasquale ; Corrado, Egle ; Pitruzzella, Valentina ; Novo, Salvatore ; Mignano, Antonino ; Novo, Giuseppina ; Arnone, Gaspare ; Arnone, M. Teresa. / Prognostic role of aldosterone in patients with acute coronary syndrome: short and medium term follow-up. In: Journal of Cardiovascular Medicine. 2013 ; Vol. 0. pagg. -.
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title = "Prognostic role of aldosterone in patients with acute coronary syndrome: short and medium term follow-up.",
abstract = "AIMS: Different studies have shown a correlation between aldosterone, atherosclerosis and ischemia in the past decade. Evidence exists for the relationship between high levels of aldosterone and augmented risk of cardiovascular diseases, such as hypertension, cardiac failure, coronary artery disease and stroke. The objective of this study was to determine the prognostic role of aldosterone in patients with myocardial infarction. METHODS:The study population included 96 consecutive patients admitted to our department for ST-elevated and non-ST-elevated myocardial infarction from June 2009 to March 2012. Plasma aldosterone levels were measured at admission to hospital in all patients. A 2-year prospective follow-up was performed, and fatal events and non-fatal events, such as reinfarction, congestive heart failure and arrhythmias, were recorded. RESULTS:Aldosterone levels at admission were associated with incidence of congestive heart failure (P = 0.02), ventricular arrhythmias (P = 0.01) and all complications (P = 0.003) after 1-month follow-up. Moreover, high aldosterone levels gave important information in the medium term (24 ± 6 months). Specifically, aldosterone was a predictive variable of reinfarction (P < 0.0001), congestive heart failure (P < 0.0001) and adverse events (P = 0.0002). The logistic regression analysis confirmed these results and showed that aldosterone may be predictive of adverse events at medium-term follow-up (odds ratio 1.1, 95{\%} confidence interval 1.03-1.15, P = 0.02). CONCLUSION:These data show a strong and significant correlation between plasma aldosterone levels at admission for myocardial infarction and fatal and nonfatal adverse events. Aldosterone appears to be a main marker of adverse clinical outcome, in accordance with the literature. These data suggest the need to identify whether antialdosteronic drug treatment, applied acutely in patients with aldosterone elevation, can influence favorably the prognosis of patients with myocardial infarction.",
author = "Pasquale Assennato and Salvatore Novo and Giuseppina Novo and Valentina Pitruzzella and Egle Corrado and Antonino Mignano and Antonino Rotolo and Pasquale Assennato and Egle Corrado and Valentina Pitruzzella and Salvatore Novo and Antonino Mignano and Giuseppina Novo and Gaspare Arnone and Arnone, {M. Teresa}",
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TY - JOUR

T1 - Prognostic role of aldosterone in patients with acute coronary syndrome: short and medium term follow-up.

AU - Assennato, Pasquale

AU - Novo, Salvatore

AU - Novo, Giuseppina

AU - Pitruzzella, Valentina

AU - Corrado, Egle

AU - Mignano, Antonino

AU - Rotolo, Antonino

AU - Assennato, Pasquale

AU - Corrado, Egle

AU - Pitruzzella, Valentina

AU - Novo, Salvatore

AU - Mignano, Antonino

AU - Novo, Giuseppina

AU - Arnone, Gaspare

AU - Arnone, M. Teresa

PY - 2013

Y1 - 2013

N2 - AIMS: Different studies have shown a correlation between aldosterone, atherosclerosis and ischemia in the past decade. Evidence exists for the relationship between high levels of aldosterone and augmented risk of cardiovascular diseases, such as hypertension, cardiac failure, coronary artery disease and stroke. The objective of this study was to determine the prognostic role of aldosterone in patients with myocardial infarction. METHODS:The study population included 96 consecutive patients admitted to our department for ST-elevated and non-ST-elevated myocardial infarction from June 2009 to March 2012. Plasma aldosterone levels were measured at admission to hospital in all patients. A 2-year prospective follow-up was performed, and fatal events and non-fatal events, such as reinfarction, congestive heart failure and arrhythmias, were recorded. RESULTS:Aldosterone levels at admission were associated with incidence of congestive heart failure (P = 0.02), ventricular arrhythmias (P = 0.01) and all complications (P = 0.003) after 1-month follow-up. Moreover, high aldosterone levels gave important information in the medium term (24 ± 6 months). Specifically, aldosterone was a predictive variable of reinfarction (P < 0.0001), congestive heart failure (P < 0.0001) and adverse events (P = 0.0002). The logistic regression analysis confirmed these results and showed that aldosterone may be predictive of adverse events at medium-term follow-up (odds ratio 1.1, 95% confidence interval 1.03-1.15, P = 0.02). CONCLUSION:These data show a strong and significant correlation between plasma aldosterone levels at admission for myocardial infarction and fatal and nonfatal adverse events. Aldosterone appears to be a main marker of adverse clinical outcome, in accordance with the literature. These data suggest the need to identify whether antialdosteronic drug treatment, applied acutely in patients with aldosterone elevation, can influence favorably the prognosis of patients with myocardial infarction.

AB - AIMS: Different studies have shown a correlation between aldosterone, atherosclerosis and ischemia in the past decade. Evidence exists for the relationship between high levels of aldosterone and augmented risk of cardiovascular diseases, such as hypertension, cardiac failure, coronary artery disease and stroke. The objective of this study was to determine the prognostic role of aldosterone in patients with myocardial infarction. METHODS:The study population included 96 consecutive patients admitted to our department for ST-elevated and non-ST-elevated myocardial infarction from June 2009 to March 2012. Plasma aldosterone levels were measured at admission to hospital in all patients. A 2-year prospective follow-up was performed, and fatal events and non-fatal events, such as reinfarction, congestive heart failure and arrhythmias, were recorded. RESULTS:Aldosterone levels at admission were associated with incidence of congestive heart failure (P = 0.02), ventricular arrhythmias (P = 0.01) and all complications (P = 0.003) after 1-month follow-up. Moreover, high aldosterone levels gave important information in the medium term (24 ± 6 months). Specifically, aldosterone was a predictive variable of reinfarction (P < 0.0001), congestive heart failure (P < 0.0001) and adverse events (P = 0.0002). The logistic regression analysis confirmed these results and showed that aldosterone may be predictive of adverse events at medium-term follow-up (odds ratio 1.1, 95% confidence interval 1.03-1.15, P = 0.02). CONCLUSION:These data show a strong and significant correlation between plasma aldosterone levels at admission for myocardial infarction and fatal and nonfatal adverse events. Aldosterone appears to be a main marker of adverse clinical outcome, in accordance with the literature. These data suggest the need to identify whether antialdosteronic drug treatment, applied acutely in patients with aldosterone elevation, can influence favorably the prognosis of patients with myocardial infarction.

UR - http://hdl.handle.net/10447/85643

M3 - Article

VL - 0

SP - -

JO - Journal of Cardiovascular Medicine

JF - Journal of Cardiovascular Medicine

SN - 1558-2027

ER -