Prognostic Implications of the Complement Protein C1q in Gliomas

Vito Rodolico, Beatrice Belmonte, Chiara Agostinis, Alessandro Mangogna, Deborah Bonazza, Paola Zacchi, Fabrizio Zanconati, Uday Kishore, Roberta Bulla

Risultato della ricerca: Article

Abstract

The contribution of the complement system in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis. Complement system represents an important component of the inflammatory response, which acts as a functional bridge between the innate and adaptive immune response. C1q, the first recognition subcomponent of the complement classical pathway, has recently been shown to be involved in a range of pathophysiological functions that are not dependent on complement activation. C1q is expressed in the microenvironment of various types of human tumors, including melanoma, prostate, mesothelioma, and ovarian cancers, where it can exert a protective or a harmful effect on cancer progression. Despite local synthesis of C1q in the central nervous system, the involvement of C1q in glioma pathogenesis has been poorly investigated. We, therefore, performed a bioinformatics analysis, using Oncomine dataset and UALCAN database in order to assess whether the expression of the genes encoding for the three chains of C1q (C1qA, C1qB, and C1qC) could serve as a potential prognostic marker for gliomas. The obtained results were then validated using an independent glioma cohort from the Chinese Glioma Genome Atlas datasets. Our bioinformatics analysis, coupled with immunohistochemistry and fluorescence microscopy, appears to suggest a positive correlation between higher levels of C1q expression and unfavorable prognosis in a diverse grade of gliomas.
Lingua originaleEnglish
Numero di pagine11
RivistaFrontiers in Immunology
Volume10
Stato di pubblicazionePublished - 2019

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Complement C1q
Glioma
Complement System Proteins
Computational Biology
Classical Complement Pathway
Atlases
Complement Activation
Mesothelioma
Adaptive Immunity
Fluorescence Microscopy
Innate Immunity
Brain Neoplasms
Ovarian Neoplasms
Melanoma
Neoplasms
Prostatic Neoplasms
Carcinogenesis
Central Nervous System
Immunohistochemistry
Genome

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cita questo

Rodolico, V., Belmonte, B., Agostinis, C., Mangogna, A., Bonazza, D., Zacchi, P., ... Bulla, R. (2019). Prognostic Implications of the Complement Protein C1q in Gliomas. Frontiers in Immunology, 10.

Prognostic Implications of the Complement Protein C1q in Gliomas. / Rodolico, Vito; Belmonte, Beatrice; Agostinis, Chiara; Mangogna, Alessandro; Bonazza, Deborah; Zacchi, Paola; Zanconati, Fabrizio; Kishore, Uday; Bulla, Roberta.

In: Frontiers in Immunology, Vol. 10, 2019.

Risultato della ricerca: Article

Rodolico, V, Belmonte, B, Agostinis, C, Mangogna, A, Bonazza, D, Zacchi, P, Zanconati, F, Kishore, U & Bulla, R 2019, 'Prognostic Implications of the Complement Protein C1q in Gliomas', Frontiers in Immunology, vol. 10.
Rodolico, Vito ; Belmonte, Beatrice ; Agostinis, Chiara ; Mangogna, Alessandro ; Bonazza, Deborah ; Zacchi, Paola ; Zanconati, Fabrizio ; Kishore, Uday ; Bulla, Roberta. / Prognostic Implications of the Complement Protein C1q in Gliomas. In: Frontiers in Immunology. 2019 ; Vol. 10.
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AU - Rodolico, Vito

AU - Belmonte, Beatrice

AU - Agostinis, Chiara

AU - Mangogna, Alessandro

AU - Bonazza, Deborah

AU - Zacchi, Paola

AU - Zanconati, Fabrizio

AU - Kishore, Uday

AU - Bulla, Roberta

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N2 - The contribution of the complement system in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis. Complement system represents an important component of the inflammatory response, which acts as a functional bridge between the innate and adaptive immune response. C1q, the first recognition subcomponent of the complement classical pathway, has recently been shown to be involved in a range of pathophysiological functions that are not dependent on complement activation. C1q is expressed in the microenvironment of various types of human tumors, including melanoma, prostate, mesothelioma, and ovarian cancers, where it can exert a protective or a harmful effect on cancer progression. Despite local synthesis of C1q in the central nervous system, the involvement of C1q in glioma pathogenesis has been poorly investigated. We, therefore, performed a bioinformatics analysis, using Oncomine dataset and UALCAN database in order to assess whether the expression of the genes encoding for the three chains of C1q (C1qA, C1qB, and C1qC) could serve as a potential prognostic marker for gliomas. The obtained results were then validated using an independent glioma cohort from the Chinese Glioma Genome Atlas datasets. Our bioinformatics analysis, coupled with immunohistochemistry and fluorescence microscopy, appears to suggest a positive correlation between higher levels of C1q expression and unfavorable prognosis in a diverse grade of gliomas.

AB - The contribution of the complement system in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis. Complement system represents an important component of the inflammatory response, which acts as a functional bridge between the innate and adaptive immune response. C1q, the first recognition subcomponent of the complement classical pathway, has recently been shown to be involved in a range of pathophysiological functions that are not dependent on complement activation. C1q is expressed in the microenvironment of various types of human tumors, including melanoma, prostate, mesothelioma, and ovarian cancers, where it can exert a protective or a harmful effect on cancer progression. Despite local synthesis of C1q in the central nervous system, the involvement of C1q in glioma pathogenesis has been poorly investigated. We, therefore, performed a bioinformatics analysis, using Oncomine dataset and UALCAN database in order to assess whether the expression of the genes encoding for the three chains of C1q (C1qA, C1qB, and C1qC) could serve as a potential prognostic marker for gliomas. The obtained results were then validated using an independent glioma cohort from the Chinese Glioma Genome Atlas datasets. Our bioinformatics analysis, coupled with immunohistochemistry and fluorescence microscopy, appears to suggest a positive correlation between higher levels of C1q expression and unfavorable prognosis in a diverse grade of gliomas.

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KW - prognostic significance of C1q

KW - survival probability

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