Probing in cell protein structural changes with time-resolved X-ray scattering

Giorgio Schiro', Antonio Cupane, Matteo Levantino, Michael Wulff, Marco Cammarata, Alessandro Spilotros

Risultato della ricerca: Article

9 Citazioni (Scopus)

Abstract

Investigating protein structural changes inside the cell is a major goal in molecular biology. Here we show that time-resolved wide-angle X-ray scattering is a valuable tool for this purpose. Hemoglobin has been chosen as a model system and its tertiary and quaternary conformational changes following laser flash-photolysis have been tracked in intact red blood cells with nanosecond time resolution.
Lingua originaleEnglish
pagine (da-a)6434-6437
Numero di pagine4
RivistaSoft Matter
Volume8
Stato di pubblicazionePublished - 2012

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics

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