Prion protein gene frequencies in three Sicilian dairy sheep populations

Baldassare Portolano, Maria Vitale, Marina Scimonelli, Francesco Pinelli, Fabrizio Vitale, Johannes B. C. H. M. Van Kaam, Santo Caracappa, Pascal A. Oltenacu, Raffaella Finocchiaro

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5 Citazioni (Scopus)

Abstract

The objective of this paper was to investigate the prion protein (PrP) genotype and haplotype frequencies in three Sicilian dairy sheep populations. The three populations were: (1) 1096 Valle del Belice animals, (2) 1143 Comisana animals, and (3) 1771 individuals from 5 flocks with scrapie outbreaks, in which the animals were crossbreds derived from indigenous Sicilian dairy breeds. PrP genotypes are described for the three codons 136 (Alanine or Valine; A, V), 154 (Histidine or Arginine; H, R), and 171 (Glutamine, Arginine or Histidine; Q, R, H) which represent polymorphisms known to be linked with scrapie susceptibility. The Valle del Belice haplotype frequencies were 32.3% ARR, 6.5% AHQ, 1.0% ARH, 58.8% ARQ, and 1.4% VRQ. The Comisana frequencies were 39.4% ARR, 2.9% AHQ, 2.9% ARH, 50.9% ARQ, and 3.9% VRQ. In the flocks with scrapie outbreaks the frequencies were 32.8% ARR, 2.4% AHQ, 1.7% ARH, 59.1% ARQ, and 3.9% VRQ. In all three populations ARQ and ARR were the most frequent haplotypes. Multiple generations of strong selection will be needed to fixate the most resistant ARR haplotype.
Lingua originaleEnglish
pagine (da-a)87-94
Numero di pagine8
RivistaItalian Journal of Animal Science
Volume7
Stato di pubblicazionePublished - 2008

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

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    Portolano, B., Vitale, M., Scimonelli, M., Pinelli, F., Vitale, F., Van Kaam, J. B. C. H. M., Caracappa, S., Oltenacu, P. A., & Finocchiaro, R. (2008). Prion protein gene frequencies in three Sicilian dairy sheep populations. Italian Journal of Animal Science, 7, 87-94.