Prevalence, management, and outcome of adverse rhythm disorders in takotsubo syndrome: insights from the international multicenter GEIST registry

Salvatore Novo, Giuseppina Novo, Ibrahim Akin, Ingo Eitel, Pasquale Caldarola, Holger Thiele, Federico Guerra, Thomas Stiermaier, Francesco Santoro, Irene Giannini, Ibrahim El-Battrawy, Christian Möller, Francesca Guastafierro, Holger Thiele, Fabiana Romeo, Holger Thiele, Francesco Santoro, Francesco Santoro, Enrica Mariano, Francesco RomeoAlessandro Capucci, Natale Daniele Brunetti

Risultato della ricerca: Articlepeer review

21 Citazioni (Scopus)


One important complication related to takotsubo syndrome (TTS) is adverse rhythm disorders. Our study was conducted to determine the incidence and management of adverse rhythm disorders in TTS and its long-term prognostic impact. We analyzed 906 TTS patients from 9 European centers. Patients were divided into the adverse rhythm disorders group (encompassing ventricular tachycardia, ventricular fibrillation, torsade de pointes, and asystole or complete atrioventricular block) and non-adverse rhythm disorders group. In our study cohort, we identified 67 (7.4%) patients with presence of adverse rhythm disorders. TTS patients were followed up over a period of 2.8 years. In the adverse rhythm disorders group, 18% of patients presented adverse rhythm disorders before hospital admission. Asystole and/or AV block were significantly more presented before admission (13 patients versus 8 patients; p < 0.01), whereas ventricular tachyarrhythmias were more presented in-hospital (4 patients versus 42 patients; p < 0.01). Adverse rhythm disorders patients suffered more frequently from cardiogenic shock (31% versus 7.6%, p < 0.01) and in-hospital death (10.9% versus 3.6%; p < 0.01). Furthermore, the long-term survival was significantly impaired in adverse rhythm disorders patients as compared with non-adverse rhythm disorders patients; (log-rank p < 0.01). Using multivariate Cox regression analysis, cardiogenic shock (HR 2.86, 95% CI 1.1-6.9; p = 0.02) was identified as independent predictors of adverse rhythm disorders. The short- and long-term mortality rate of TTS patients presenting with adverse rhythm disorders was significantly higher than in TTS patients presenting without it. Therefore, TTS patients with adverse rhythm disorders should be carefully monitored during hospital stay and at long-term follow-up.
Lingua originaleEnglish
Numero di pagine7
RivistaHeart Failure Reviews
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

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