Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics

Anna Carbone, Giuseppe Pistone, Erica Moggio, Gianfranco Altomare, Elisa Benati, Stefano Piaserico, Mario Puviani, Andrea Zanca, Margherita Raucci, Francesco Borgia, Anna Carbone, Concetta Potenza, Sergio Donato, Sergio Chimenti, Sabina Vaccari, Paolo Broganelli, Stefano Veglio, Maria Concetta Fargnoli, Giampiero Girolomoni, Giuseppe MicaliKetty Peris, Aurora Parodi

Risultato della ricerca: Article

11 Citazioni (Scopus)

Abstract

Background: Actinic keratosis (AK) is a common keratinocyte intraepidermal neoplasia. Objective: To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics. Materials &amp; methods: This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented. Results: AK prevalence in 7,284 patients was 27.4% (95% CI: 26.4-28.4%); 34.3% in men and 20.0% in women (p<0.001). Independent AK risk factors in 4,604 patients were: age (OR: 4.8 [95% CI: 3.5-6.5] for 46-60 years, increasing with older age to OR: 41.5 [95% CI: 29.5-58.2] for >70 years), history of other non-melanoma skin cancers (OR: 2.7 [2.2-3.3]), residence in southern Italy/Sardinia (OR: 2.6 [2.1-3.0]), working outdoors >6 hours/day (OR: 1.9 [1.4-2.4]), male gender (OR: 1.7 [1.4-2.0]), facial solar lentigos (OR: 1.6 [1.4-1.9]), light hair colour (OR: 1.5 [1.2-1.8]), prolonged outdoor recreational activities (OR: 1.4 [1.2-1.7]), light eye colour (OR: 1.3 [1.1-1.6]), skin type I/II (OR: 1.3 [1.1-1.6]), and alcohol consumption (OR: 1.2 [1.0-3.3]). BMI ≥25.0 (OR: 0.6 [0.5-0.7]), regular sunscreen use (OR: 0.7 [0.6-0.8]), and a lower level of education (OR: 0.8 [0.7-1.0]) were independent protective factors. Conclusions: AK prevalence was high in Italian dermatology outpatients. We confirm several well-known AK risk factors and reveal possible novel risk and protective factors. Our results may inform on the design and implementation of AK screening and educational programmes.
Lingua originaleEnglish
pagine (da-a)599-608
Numero di pagine10
RivistaEuropean Journal of Dermatology
Volume27
Stato di pubblicazionePublished - 2017

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Actinic Keratosis
Dermatology
Italy
Outpatients
Hair Color
Eye Color
Lentigo
Light
Sunscreening Agents
Skin Neoplasms
Keratinocytes
Alcohol Drinking
Statistical Factor Analysis
Retrospective Studies
Education
Skin

All Science Journal Classification (ASJC) codes

  • Dermatology

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Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics. / Carbone, Anna; Pistone, Giuseppe; Moggio, Erica; Altomare, Gianfranco; Benati, Elisa; Piaserico, Stefano; Puviani, Mario; Zanca, Andrea; Raucci, Margherita; Borgia, Francesco; Carbone, Anna; Potenza, Concetta; Donato, Sergio; Chimenti, Sergio; Vaccari, Sabina; Broganelli, Paolo; Veglio, Stefano; Fargnoli, Maria Concetta; Girolomoni, Giampiero; Micali, Giuseppe; Peris, Ketty; Parodi, Aurora.

In: European Journal of Dermatology, Vol. 27, 2017, pag. 599-608.

Risultato della ricerca: Article

Carbone, A, Pistone, G, Moggio, E, Altomare, G, Benati, E, Piaserico, S, Puviani, M, Zanca, A, Raucci, M, Borgia, F, Carbone, A, Potenza, C, Donato, S, Chimenti, S, Vaccari, S, Broganelli, P, Veglio, S, Fargnoli, MC, Girolomoni, G, Micali, G, Peris, K & Parodi, A 2017, 'Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics', European Journal of Dermatology, vol. 27, pagg. 599-608.
Carbone, Anna ; Pistone, Giuseppe ; Moggio, Erica ; Altomare, Gianfranco ; Benati, Elisa ; Piaserico, Stefano ; Puviani, Mario ; Zanca, Andrea ; Raucci, Margherita ; Borgia, Francesco ; Carbone, Anna ; Potenza, Concetta ; Donato, Sergio ; Chimenti, Sergio ; Vaccari, Sabina ; Broganelli, Paolo ; Veglio, Stefano ; Fargnoli, Maria Concetta ; Girolomoni, Giampiero ; Micali, Giuseppe ; Peris, Ketty ; Parodi, Aurora. / Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics. In: European Journal of Dermatology. 2017 ; Vol. 27. pagg. 599-608.
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title = "Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics",
abstract = "Background: Actinic keratosis (AK) is a common keratinocyte intraepidermal neoplasia. Objective: To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics. Materials & methods: This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented. Results: AK prevalence in 7,284 patients was 27.4{\%} (95{\%} CI: 26.4-28.4{\%}); 34.3{\%} in men and 20.0{\%} in women (p<0.001). Independent AK risk factors in 4,604 patients were: age (OR: 4.8 [95{\%} CI: 3.5-6.5] for 46-60 years, increasing with older age to OR: 41.5 [95{\%} CI: 29.5-58.2] for >70 years), history of other non-melanoma skin cancers (OR: 2.7 [2.2-3.3]), residence in southern Italy/Sardinia (OR: 2.6 [2.1-3.0]), working outdoors >6 hours/day (OR: 1.9 [1.4-2.4]), male gender (OR: 1.7 [1.4-2.0]), facial solar lentigos (OR: 1.6 [1.4-1.9]), light hair colour (OR: 1.5 [1.2-1.8]), prolonged outdoor recreational activities (OR: 1.4 [1.2-1.7]), light eye colour (OR: 1.3 [1.1-1.6]), skin type I/II (OR: 1.3 [1.1-1.6]), and alcohol consumption (OR: 1.2 [1.0-3.3]). BMI ≥25.0 (OR: 0.6 [0.5-0.7]), regular sunscreen use (OR: 0.7 [0.6-0.8]), and a lower level of education (OR: 0.8 [0.7-1.0]) were independent protective factors. Conclusions: AK prevalence was high in Italian dermatology outpatients. We confirm several well-known AK risk factors and reveal possible novel risk and protective factors. Our results may inform on the design and implementation of AK screening and educational programmes.",
author = "Anna Carbone and Giuseppe Pistone and Erica Moggio and Gianfranco Altomare and Elisa Benati and Stefano Piaserico and Mario Puviani and Andrea Zanca and Margherita Raucci and Francesco Borgia and Anna Carbone and Concetta Potenza and Sergio Donato and Sergio Chimenti and Sabina Vaccari and Paolo Broganelli and Stefano Veglio and Fargnoli, {Maria Concetta} and Giampiero Girolomoni and Giuseppe Micali and Ketty Peris and Aurora Parodi",
year = "2017",
language = "English",
volume = "27",
pages = "599--608",
journal = "European Journal of Dermatology",
issn = "1167-1122",
publisher = "John Libbey Eurotext",

}

TY - JOUR

T1 - Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics

AU - Carbone, Anna

AU - Pistone, Giuseppe

AU - Moggio, Erica

AU - Altomare, Gianfranco

AU - Benati, Elisa

AU - Piaserico, Stefano

AU - Puviani, Mario

AU - Zanca, Andrea

AU - Raucci, Margherita

AU - Borgia, Francesco

AU - Carbone, Anna

AU - Potenza, Concetta

AU - Donato, Sergio

AU - Chimenti, Sergio

AU - Vaccari, Sabina

AU - Broganelli, Paolo

AU - Veglio, Stefano

AU - Fargnoli, Maria Concetta

AU - Girolomoni, Giampiero

AU - Micali, Giuseppe

AU - Peris, Ketty

AU - Parodi, Aurora

PY - 2017

Y1 - 2017

N2 - Background: Actinic keratosis (AK) is a common keratinocyte intraepidermal neoplasia. Objective: To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics. Materials & methods: This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented. Results: AK prevalence in 7,284 patients was 27.4% (95% CI: 26.4-28.4%); 34.3% in men and 20.0% in women (p<0.001). Independent AK risk factors in 4,604 patients were: age (OR: 4.8 [95% CI: 3.5-6.5] for 46-60 years, increasing with older age to OR: 41.5 [95% CI: 29.5-58.2] for >70 years), history of other non-melanoma skin cancers (OR: 2.7 [2.2-3.3]), residence in southern Italy/Sardinia (OR: 2.6 [2.1-3.0]), working outdoors >6 hours/day (OR: 1.9 [1.4-2.4]), male gender (OR: 1.7 [1.4-2.0]), facial solar lentigos (OR: 1.6 [1.4-1.9]), light hair colour (OR: 1.5 [1.2-1.8]), prolonged outdoor recreational activities (OR: 1.4 [1.2-1.7]), light eye colour (OR: 1.3 [1.1-1.6]), skin type I/II (OR: 1.3 [1.1-1.6]), and alcohol consumption (OR: 1.2 [1.0-3.3]). BMI ≥25.0 (OR: 0.6 [0.5-0.7]), regular sunscreen use (OR: 0.7 [0.6-0.8]), and a lower level of education (OR: 0.8 [0.7-1.0]) were independent protective factors. Conclusions: AK prevalence was high in Italian dermatology outpatients. We confirm several well-known AK risk factors and reveal possible novel risk and protective factors. Our results may inform on the design and implementation of AK screening and educational programmes.

AB - Background: Actinic keratosis (AK) is a common keratinocyte intraepidermal neoplasia. Objective: To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics. Materials & methods: This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented. Results: AK prevalence in 7,284 patients was 27.4% (95% CI: 26.4-28.4%); 34.3% in men and 20.0% in women (p<0.001). Independent AK risk factors in 4,604 patients were: age (OR: 4.8 [95% CI: 3.5-6.5] for 46-60 years, increasing with older age to OR: 41.5 [95% CI: 29.5-58.2] for >70 years), history of other non-melanoma skin cancers (OR: 2.7 [2.2-3.3]), residence in southern Italy/Sardinia (OR: 2.6 [2.1-3.0]), working outdoors >6 hours/day (OR: 1.9 [1.4-2.4]), male gender (OR: 1.7 [1.4-2.0]), facial solar lentigos (OR: 1.6 [1.4-1.9]), light hair colour (OR: 1.5 [1.2-1.8]), prolonged outdoor recreational activities (OR: 1.4 [1.2-1.7]), light eye colour (OR: 1.3 [1.1-1.6]), skin type I/II (OR: 1.3 [1.1-1.6]), and alcohol consumption (OR: 1.2 [1.0-3.3]). BMI ≥25.0 (OR: 0.6 [0.5-0.7]), regular sunscreen use (OR: 0.7 [0.6-0.8]), and a lower level of education (OR: 0.8 [0.7-1.0]) were independent protective factors. Conclusions: AK prevalence was high in Italian dermatology outpatients. We confirm several well-known AK risk factors and reveal possible novel risk and protective factors. Our results may inform on the design and implementation of AK screening and educational programmes.

UR - http://hdl.handle.net/10447/345172

M3 - Article

VL - 27

SP - 599

EP - 608

JO - European Journal of Dermatology

JF - European Journal of Dermatology

SN - 1167-1122

ER -