Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics

Anna Carbone, Giuseppe Pistone, Erica Moggio, Gianfranco Altomare, Elisa Benati, Stefano Piaserico, Mario Puviani, Andrea Zanca, Margherita Raucci, Francesco Borgia, Anna Carbone, Concetta Potenza, Sergio Donato, Stefano Piaserico, Sergio Chimenti, Sabina Vaccari, Paolo Broganelli, Stefano Veglio, Maria Concetta Fargnoli, Giampiero GirolomoniGiuseppe Micali, Ketty Peris, Aurora Parodi

Risultato della ricerca: Articlepeer review

26 Citazioni (Scopus)


Background: Actinic keratosis (AK) is a common keratinocyte intraepidermal neoplasia. Objective: To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics. Materials & methods: This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented. Results: AK prevalence in 7,284 patients was 27.4% (95% CI: 26.4-28.4%); 34.3% in men and 20.0% in women (p<0.001). Independent AK risk factors in 4,604 patients were: age (OR: 4.8 [95% CI: 3.5-6.5] for 46-60 years, increasing with older age to OR: 41.5 [95% CI: 29.5-58.2] for >70 years), history of other non-melanoma skin cancers (OR: 2.7 [2.2-3.3]), residence in southern Italy/Sardinia (OR: 2.6 [2.1-3.0]), working outdoors >6 hours/day (OR: 1.9 [1.4-2.4]), male gender (OR: 1.7 [1.4-2.0]), facial solar lentigos (OR: 1.6 [1.4-1.9]), light hair colour (OR: 1.5 [1.2-1.8]), prolonged outdoor recreational activities (OR: 1.4 [1.2-1.7]), light eye colour (OR: 1.3 [1.1-1.6]), skin type I/II (OR: 1.3 [1.1-1.6]), and alcohol consumption (OR: 1.2 [1.0-3.3]). BMI ≥25.0 (OR: 0.6 [0.5-0.7]), regular sunscreen use (OR: 0.7 [0.6-0.8]), and a lower level of education (OR: 0.8 [0.7-1.0]) were independent protective factors. Conclusions: AK prevalence was high in Italian dermatology outpatients. We confirm several well-known AK risk factors and reveal possible novel risk and protective factors. Our results may inform on the design and implementation of AK screening and educational programmes.
Lingua originaleEnglish
pagine (da-a)599-608
Numero di pagine10
RivistaEuropean Journal of Dermatology
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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