TY - JOUR
T1 - Presepsin and Midregional Proadrenomedullin in Pediatric Oncologic Patients with Febrile Neutropenia
AU - Agnello, Luisa
AU - Bivona, Giulia
AU - Giglio, Rosaria Vincenza
AU - Ciaccio, Marcello
AU - Ciaccio, Marcello
AU - Giglio, Rosaria Vincenza
AU - Parisi, Elisa
AU - Iacona, Alessandro
AU - Lucido, Giuseppe Dejan
AU - Ziino, Ottavio
AU - Ziino, Ottavio
AU - Iacona, Alessandro
AU - Parisi, Elisa
AU - Lucido, Giuseppe Dejan
PY - 2020
Y1 - 2020
N2 - Objective: In this study, we investigated the roles of presepsin (PSP) and midregional proadrenomedullin (mr-proADM) in children with febrile neutropenia (FN) due to chemotherapy.Methods: We assessed 36 FN episodes in 26 children. Patients were classified into bacteremia (B) and fever of unknown origin (FUO) groups. We evaluated PSP and mr-proADM at admission (T0), after 24/48 h (T1), and after 5 days (T2).Results: PSP and mr-proADM levels were elevated at T0 and significantly decreased at T2. mr-proADM levels did not significantly differ between the B and FUO groups. PSP levels significantly differed between the B and FUO groups only at T1. Both PSP and mr-proADM levels at T0 were a predictor of length of hospital stay but not of the duration of fever. Finally, receiver operating characteristic curve analysis showed that PSP and mr-proADM had low diagnostic accuracy for blood culture positivity.Conclusion: PSP and mr-proADM display poor clinical usefulness for FN in oncologic children.
AB - Objective: In this study, we investigated the roles of presepsin (PSP) and midregional proadrenomedullin (mr-proADM) in children with febrile neutropenia (FN) due to chemotherapy.Methods: We assessed 36 FN episodes in 26 children. Patients were classified into bacteremia (B) and fever of unknown origin (FUO) groups. We evaluated PSP and mr-proADM at admission (T0), after 24/48 h (T1), and after 5 days (T2).Results: PSP and mr-proADM levels were elevated at T0 and significantly decreased at T2. mr-proADM levels did not significantly differ between the B and FUO groups. PSP levels significantly differed between the B and FUO groups only at T1. Both PSP and mr-proADM levels at T0 were a predictor of length of hospital stay but not of the duration of fever. Finally, receiver operating characteristic curve analysis showed that PSP and mr-proADM had low diagnostic accuracy for blood culture positivity.Conclusion: PSP and mr-proADM display poor clinical usefulness for FN in oncologic children.
UR - http://hdl.handle.net/10447/419303
M3 - Article
SN - 0007-5027
JO - Laboratory Medicine
JF - Laboratory Medicine
ER -