Preparation and XAFS Studies of Organotin(IV)Complexes with Adenosine and Related Compounds and Calf Thymus DNA

Lorenzo Pellerito, Michelangelo Scopelliti, Jankovics, Attila Szorcsik, Sletten, László Nagy, Yamaguchi, Yoshida

Risultato della ricerca: Article

3 Citazioni (Scopus)

Abstract

Complexes of adenosine and related compounds (adenosine-5’-monophosphate, adenosine-5’-triphosphate and pyridoxal-5-phosphate) with Bu2SnO and/or BuSnCl2 were prepared in the solid state. The compositions of the complexes were determined by standard analytical methods. It was found that the complexes contain the organotin(IV) moiety and the ligand in a ratio of 1 : 1. The FT-IR spectra demonstrated that Bu2SnO reacts with the D-ribose moiety of the ligands, while Bu2SnCl2 is coordinated to the deprotonated phosphate group. The basic part of the ligands does not participate directly in complex formation. Comparison of the experimental Mössbauer quadrupole splitting values with those calculated on the basis of the pqs concept revealed that the organotin(IV) moiety has Tbp and in some cases also Th geometry. The adenosine complex contains the organotin(IV) cation in two different surroundings (Tbp and Th). The local structures of the complexes were determined by means of EXAFS measurements. At the same time a number of organotin(IV) complexes containing different organo moieties of calf thymus DNA were also prepared. Similarly as above, EXAFS data were obtained for these compounds and analyzed by using multishell models up to 300 pm. These results are the first structural data (bond lengths) on complexes formed with organotin(IV)-DNA and related compounds.
Lingua originaleEnglish
pagine (da-a)193-200
Numero di pagine8
RivistaJournal of Radioanalytical and Nuclear Chemistry
Volume275
Stato di pubblicazionePublished - 2008

Fingerprint

Thymus
Adenosine
DNA
Ligands
Phosphates
Pyridoxal Phosphate
Ribose
Bond length
Adenosine Monophosphate
Cations
Adenosine Triphosphate
Positive ions
Geometry
Chemical analysis
calf thymus DNA

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Spectroscopy
  • Pollution
  • Radiology Nuclear Medicine and imaging
  • Nuclear Energy and Engineering

Cita questo

Preparation and XAFS Studies of Organotin(IV)Complexes with Adenosine and Related Compounds and Calf Thymus DNA. / Pellerito, Lorenzo; Scopelliti, Michelangelo; Jankovics; Szorcsik, Attila; Sletten; Nagy, László; Yamaguchi; Yoshida.

In: Journal of Radioanalytical and Nuclear Chemistry, Vol. 275, 2008, pag. 193-200.

Risultato della ricerca: Article

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abstract = "Complexes of adenosine and related compounds (adenosine-5’-monophosphate, adenosine-5’-triphosphate and pyridoxal-5-phosphate) with Bu2SnO and/or BuSnCl2 were prepared in the solid state. The compositions of the complexes were determined by standard analytical methods. It was found that the complexes contain the organotin(IV) moiety and the ligand in a ratio of 1 : 1. The FT-IR spectra demonstrated that Bu2SnO reacts with the D-ribose moiety of the ligands, while Bu2SnCl2 is coordinated to the deprotonated phosphate group. The basic part of the ligands does not participate directly in complex formation. Comparison of the experimental M{\"o}ssbauer quadrupole splitting values with those calculated on the basis of the pqs concept revealed that the organotin(IV) moiety has Tbp and in some cases also Th geometry. The adenosine complex contains the organotin(IV) cation in two different surroundings (Tbp and Th). The local structures of the complexes were determined by means of EXAFS measurements. At the same time a number of organotin(IV) complexes containing different organo moieties of calf thymus DNA were also prepared. Similarly as above, EXAFS data were obtained for these compounds and analyzed by using multishell models up to 300 pm. These results are the first structural data (bond lengths) on complexes formed with organotin(IV)-DNA and related compounds.",
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author = "Lorenzo Pellerito and Michelangelo Scopelliti and Jankovics and Attila Szorcsik and Sletten and L{\'a}szl{\'o} Nagy and Yamaguchi and Yoshida",
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TY - JOUR

T1 - Preparation and XAFS Studies of Organotin(IV)Complexes with Adenosine and Related Compounds and Calf Thymus DNA

AU - Pellerito, Lorenzo

AU - Scopelliti, Michelangelo

AU - Jankovics, null

AU - Szorcsik, Attila

AU - Sletten, null

AU - Nagy, László

AU - Yamaguchi, null

AU - Yoshida, null

PY - 2008

Y1 - 2008

N2 - Complexes of adenosine and related compounds (adenosine-5’-monophosphate, adenosine-5’-triphosphate and pyridoxal-5-phosphate) with Bu2SnO and/or BuSnCl2 were prepared in the solid state. The compositions of the complexes were determined by standard analytical methods. It was found that the complexes contain the organotin(IV) moiety and the ligand in a ratio of 1 : 1. The FT-IR spectra demonstrated that Bu2SnO reacts with the D-ribose moiety of the ligands, while Bu2SnCl2 is coordinated to the deprotonated phosphate group. The basic part of the ligands does not participate directly in complex formation. Comparison of the experimental Mössbauer quadrupole splitting values with those calculated on the basis of the pqs concept revealed that the organotin(IV) moiety has Tbp and in some cases also Th geometry. The adenosine complex contains the organotin(IV) cation in two different surroundings (Tbp and Th). The local structures of the complexes were determined by means of EXAFS measurements. At the same time a number of organotin(IV) complexes containing different organo moieties of calf thymus DNA were also prepared. Similarly as above, EXAFS data were obtained for these compounds and analyzed by using multishell models up to 300 pm. These results are the first structural data (bond lengths) on complexes formed with organotin(IV)-DNA and related compounds.

AB - Complexes of adenosine and related compounds (adenosine-5’-monophosphate, adenosine-5’-triphosphate and pyridoxal-5-phosphate) with Bu2SnO and/or BuSnCl2 were prepared in the solid state. The compositions of the complexes were determined by standard analytical methods. It was found that the complexes contain the organotin(IV) moiety and the ligand in a ratio of 1 : 1. The FT-IR spectra demonstrated that Bu2SnO reacts with the D-ribose moiety of the ligands, while Bu2SnCl2 is coordinated to the deprotonated phosphate group. The basic part of the ligands does not participate directly in complex formation. Comparison of the experimental Mössbauer quadrupole splitting values with those calculated on the basis of the pqs concept revealed that the organotin(IV) moiety has Tbp and in some cases also Th geometry. The adenosine complex contains the organotin(IV) cation in two different surroundings (Tbp and Th). The local structures of the complexes were determined by means of EXAFS measurements. At the same time a number of organotin(IV) complexes containing different organo moieties of calf thymus DNA were also prepared. Similarly as above, EXAFS data were obtained for these compounds and analyzed by using multishell models up to 300 pm. These results are the first structural data (bond lengths) on complexes formed with organotin(IV)-DNA and related compounds.

KW - XAFS, organotin(IV), DNA, Mossbauer, FT-IR

UR - http://hdl.handle.net/10447/35723

M3 - Article

VL - 275

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JO - Journal of Radioanalytical Chemistry

JF - Journal of Radioanalytical Chemistry

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