TY - CONF
T1 - Preparation and characterization of PLLA-HA scaffolds for bone tissue engineering
AU - La Carrubba, Vincenzo
AU - Carfi' Pavia, Francesco
AU - Brucato, Valerio Maria Bartolo
PY - 2013
Y1 - 2013
N2 - In this work, the possibility to produce composite - Poly-L-lactic acid (PLLA) and Hydroxyapatite (HA) - porous scaffolds via Thermally Induced Phase Separation for bone tissue engineering applications was investigated. Several PLLA/HA ratios were tested (70/30, 50/50, 30/70 and 20/80 wt/wt) and the as-obtained scaffolds were characterized via Scanning Electron Microscopy (SEM), Wide Angle X-Ray Diffraction (WAXD) and compression test. The results showed that the presence of HA does not influence the phase separation process. Morphological analysis revealed an open structure with interconnected pores and HA embedded in the polymer matrix. This evidence was confirmed by WAXD analysis; where the typical peaks of PLLA and HA appear. Finally, an increase of the young modulus was observed in the composite scaffolds with respect to pure PLLA scaffolds.
AB - In this work, the possibility to produce composite - Poly-L-lactic acid (PLLA) and Hydroxyapatite (HA) - porous scaffolds via Thermally Induced Phase Separation for bone tissue engineering applications was investigated. Several PLLA/HA ratios were tested (70/30, 50/50, 30/70 and 20/80 wt/wt) and the as-obtained scaffolds were characterized via Scanning Electron Microscopy (SEM), Wide Angle X-Ray Diffraction (WAXD) and compression test. The results showed that the presence of HA does not influence the phase separation process. Morphological analysis revealed an open structure with interconnected pores and HA embedded in the polymer matrix. This evidence was confirmed by WAXD analysis; where the typical peaks of PLLA and HA appear. Finally, an increase of the young modulus was observed in the composite scaffolds with respect to pure PLLA scaffolds.
UR - http://hdl.handle.net/10447/100144
M3 - Other
ER -