Gold nanorods (AuNRs) can combine therapeutic hyperthermia with diagnostic features,representing a smart choice to address personalized cancer treatments. In this regard, a crucial questis the selection of the right biocompatible coating agent able to stabilize them in the physiologicalenvironment, further endowing the possibility to load bioactive molecules and/or targeting moieties.Therefore, AuNRs optical properties can be successfully merged with advantageous materials featuresto obtain selective photothermal therapy (PTT) systems. Here, the natural materials lipoic acid(LA) and the polysaccharide gellan gum (GG) were chosen to prepare three types of stabilized goldnanorods, using LA (AuNRs/LA), a layered coating of LA and GG (AuNRs/LA,GG) or a newlysynthesized covalent derivative of LA and GG (AuNRs/GG-LA). The samples displayed diversestability and dispersibility. Hydrodynamic diameters and surface potential analyses confirmed thenanometric size (100–200 nm) and showed surface charges ranging from +19.5 to 25.6 mV. Particularattention was thus paid to analyze the dierences between hyperthermia properties exhibited afternear-infrared (NIR) laser irradiation. Furthermore, the cytocompatibility and photothermal eectwere tested on HCT116 human colon cancer cell line. Collected data have finally allowed selectingAuNRs/LA,GG as the best candidate for possible use in PTT of cancer.
|Numero di pagine||18|
|Stato di pubblicazione||Published - 2020|