Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy

Maurizio Marrale, Cesare Gagliardo, Marco D'Amelio, Massimo Midiri, Giorgio Collura, Roberto Cannella, Tommaso Vincenzo Bartolotta, Domenico Iacopino, Patrizia Toia, Antonia Pignolo, Alessandro Napoli, Alessandro Napoli, Carlo Catalano, Giuseppe Filorizzo, Rosario Maugeri

Risultato della ricerca: Articlepeer review


The prevalence and impact of imaging findings detected during screening procedures in patients undergoing transcranial MR-guided Focused Ultrasound (tcMRgFUS) thalamotomy for functional neurological disorders has not been assessed yet. This study included 90 patients who fully completed clinical and neuroradiological screenings for tcMRgFUS in a single-center. The presence and location of preoperative imaging findings that could impact the treatment were recorded and classified in three different groups according to their relevance for the eligibility and treatment planning. Furthermore, tcMRgFUS treatments were reviewed to evaluate the number of transducer elements turned off after marking as no pass regions the depicted imaging finding. A total of 146 preoperative imaging findings in 79 (87.8%) patients were detected in the screening population, with a significant correlation with patients’ age (rho = 483, p < 0.001). With regard of the group classification, 119 (81.5%), 26 (17.8%) were classified as group 1 or 2, respectively. One patient had group 3 finding and was considered ineligible. No complications related to the preoperative imaging findings occurred in treated patients. Preoperative neuroradiological findings are frequent in candidates to tcMRgFUS and their identification may require the placement of additional no-pass regions to prevent harmful non-targeted heating.
Lingua originaleEnglish
pagine (da-a)2524-
Numero di pagine11
RivistaScientific Reports
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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