Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique

Walter Mazzucco, Claudia Marotta, Annalisa Saracino, Laura Monno, Giovanni Putoto, Kajal Chhaganlal, Damiano Pizzol, Nicola Veronese, Francesco Di Gennaro, Jorge Moiane

Risultato della ricerca: Article

7 Citazioni (Scopus)

Abstract

Objective: Tuberculosis (TB) remains a major global health issue, ranking in the top ten causes of death worldwide. A deep understanding of factors in uencing poor treatment outcomes may allow the development of additional treatment strategies, focused on the most vulnerable groups. Aims of the study were: (i) to evaluate the treatment outcome among TB subjects followed in an outpatient setting and (ii) to analyze factors associated with treatment failure in newly diagnosed patients with pulmonary TB in Beira, the second largest city of Mozambique. Results: A total of 301 TB adult patients (32.6% females) were enrolled. Among them, 62 (20.6%) experienced a treat- ment failure over a 6 months follow-up. On multivariate model, being males (O.R. = 1.73; 95% CI 1.28–2.15), absence of education (O.R. = 1.85; 95% CI 1.02–2.95), monthly income under 50 dollars (O.R. = 1.74; 95% CI 1.24–2.21) and being employed (O.R. = 1.57; 95% CI 1.21–1.70), low body mass index values (O.R. = 1.42; 95% CI 1.18–1.72) and HIV status (O.R. = 1.42; 95% CI 1.10–1.78) increased the likelihood of therapy failure over 6 months of follow-up. In this study, patients who need more medical attention were young males, malnourished, with low income and low educa- tional degree and HIV positive. These subjects were more likely to fail therapy.
Lingua originaleEnglish
pagine (da-a)00-
Numero di pagine6
RivistaBMC Research Notes
Volume11
Stato di pubblicazionePublished - 2018

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Mozambique
Pulmonary Tuberculosis
Tuberculosis
Education
Health
Treatment Failure
HIV
Statistical Factor Analysis
Cause of Death
Body Mass Index
Outpatients
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique. / Mazzucco, Walter; Marotta, Claudia; Saracino, Annalisa; Monno, Laura; Putoto, Giovanni; Chhaganlal, Kajal; Pizzol, Damiano; Veronese, Nicola; Di Gennaro, Francesco; Moiane, Jorge.

In: BMC Research Notes, Vol. 11, 2018, pag. 00-.

Risultato della ricerca: Article

Mazzucco, W, Marotta, C, Saracino, A, Monno, L, Putoto, G, Chhaganlal, K, Pizzol, D, Veronese, N, Di Gennaro, F & Moiane, J 2018, 'Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique', BMC Research Notes, vol. 11, pagg. 00-.
Mazzucco, Walter ; Marotta, Claudia ; Saracino, Annalisa ; Monno, Laura ; Putoto, Giovanni ; Chhaganlal, Kajal ; Pizzol, Damiano ; Veronese, Nicola ; Di Gennaro, Francesco ; Moiane, Jorge. / Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique. In: BMC Research Notes. 2018 ; Vol. 11. pagg. 00-.
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abstract = "Objective: Tuberculosis (TB) remains a major global health issue, ranking in the top ten causes of death worldwide. A deep understanding of factors in uencing poor treatment outcomes may allow the development of additional treatment strategies, focused on the most vulnerable groups. Aims of the study were: (i) to evaluate the treatment outcome among TB subjects followed in an outpatient setting and (ii) to analyze factors associated with treatment failure in newly diagnosed patients with pulmonary TB in Beira, the second largest city of Mozambique. Results: A total of 301 TB adult patients (32.6{\%} females) were enrolled. Among them, 62 (20.6{\%}) experienced a treat- ment failure over a 6 months follow-up. On multivariate model, being males (O.R. = 1.73; 95{\%} CI 1.28–2.15), absence of education (O.R. = 1.85; 95{\%} CI 1.02–2.95), monthly income under 50 dollars (O.R. = 1.74; 95{\%} CI 1.24–2.21) and being employed (O.R. = 1.57; 95{\%} CI 1.21–1.70), low body mass index values (O.R. = 1.42; 95{\%} CI 1.18–1.72) and HIV status (O.R. = 1.42; 95{\%} CI 1.10–1.78) increased the likelihood of therapy failure over 6 months of follow-up. In this study, patients who need more medical attention were young males, malnourished, with low income and low educa- tional degree and HIV positive. These subjects were more likely to fail therapy.",
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AU - Mazzucco, Walter

AU - Marotta, Claudia

AU - Saracino, Annalisa

AU - Monno, Laura

AU - Putoto, Giovanni

AU - Chhaganlal, Kajal

AU - Pizzol, Damiano

AU - Veronese, Nicola

AU - Di Gennaro, Francesco

AU - Moiane, Jorge

PY - 2018

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N2 - Objective: Tuberculosis (TB) remains a major global health issue, ranking in the top ten causes of death worldwide. A deep understanding of factors in uencing poor treatment outcomes may allow the development of additional treatment strategies, focused on the most vulnerable groups. Aims of the study were: (i) to evaluate the treatment outcome among TB subjects followed in an outpatient setting and (ii) to analyze factors associated with treatment failure in newly diagnosed patients with pulmonary TB in Beira, the second largest city of Mozambique. Results: A total of 301 TB adult patients (32.6% females) were enrolled. Among them, 62 (20.6%) experienced a treat- ment failure over a 6 months follow-up. On multivariate model, being males (O.R. = 1.73; 95% CI 1.28–2.15), absence of education (O.R. = 1.85; 95% CI 1.02–2.95), monthly income under 50 dollars (O.R. = 1.74; 95% CI 1.24–2.21) and being employed (O.R. = 1.57; 95% CI 1.21–1.70), low body mass index values (O.R. = 1.42; 95% CI 1.18–1.72) and HIV status (O.R. = 1.42; 95% CI 1.10–1.78) increased the likelihood of therapy failure over 6 months of follow-up. In this study, patients who need more medical attention were young males, malnourished, with low income and low educa- tional degree and HIV positive. These subjects were more likely to fail therapy.

AB - Objective: Tuberculosis (TB) remains a major global health issue, ranking in the top ten causes of death worldwide. A deep understanding of factors in uencing poor treatment outcomes may allow the development of additional treatment strategies, focused on the most vulnerable groups. Aims of the study were: (i) to evaluate the treatment outcome among TB subjects followed in an outpatient setting and (ii) to analyze factors associated with treatment failure in newly diagnosed patients with pulmonary TB in Beira, the second largest city of Mozambique. Results: A total of 301 TB adult patients (32.6% females) were enrolled. Among them, 62 (20.6%) experienced a treat- ment failure over a 6 months follow-up. On multivariate model, being males (O.R. = 1.73; 95% CI 1.28–2.15), absence of education (O.R. = 1.85; 95% CI 1.02–2.95), monthly income under 50 dollars (O.R. = 1.74; 95% CI 1.24–2.21) and being employed (O.R. = 1.57; 95% CI 1.21–1.70), low body mass index values (O.R. = 1.42; 95% CI 1.18–1.72) and HIV status (O.R. = 1.42; 95% CI 1.10–1.78) increased the likelihood of therapy failure over 6 months of follow-up. In this study, patients who need more medical attention were young males, malnourished, with low income and low educa- tional degree and HIV positive. These subjects were more likely to fail therapy.

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