Predictors of Hepatitis B Surface Antigen Titers two decades after vaccination in a cohort of students and post-graduates of the Medical School at the University of Palermo, Italy

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Abstract

Introduction and objective. The introduction of a vaccine against hepatitis B virus (HBV) for newborn babies in Italy in 1991, extended to 12-year-old children for the first 12 years of application, has been a major achievement in terms of theprevention of HBV infection. The objective of this study was to analyse the long-term immunogenicity and effectiveness of HBV vaccination among healthcare students with different working seniorities.Materials and method. A cross-sectional observational study of undergraduate and postgraduate students attending the Medical School of the University of Palermo was conducted from January 2014 – July 2016. HBV serum markers were performed with commercial chemiluminescence assays. Categorical variables were analyzed using the chi-square test (Mantel–Haenszel), whereas means were compared by using the Student’s t test. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were also calculated by a multivariable logistic regression, using a model constructed to examine predictors of anti-HBs titer above 10 mIU/mL, assumed as protective. Results. Of the 2,114 subjects evaluated – all vaccinated at infancy or at the age of 12 years and were HBsAg/anti-HBc negative – 806 (38.1%) had an anti-HBs titre <10 IU/L. The latter were younger, more likely to be attending a healthcareprofession school (i.e., nursing and midwifery), than a medical postgraduate level school, and more likely to have been vaccinated in infancy (p <0.001, 95% CI 2.63–5.26, adjusted OR 3.70).Conclusion. The results of the study suggest that assessment of HBV serum markers in workers potentially exposed to hospital infections is useful for identifying small numbers of unvaccinated subjects, or vaccinated subjects with low antibody titre, all of whom should be referred to a booster series of vaccinations.
Lingua originaleEnglish
pagine (da-a)303-306
Numero di pagine4
RivistaDefault journal
Volume24
Stato di pubblicazionePublished - 2017

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hepatitis
Hepatitis B virus
vaccination
Hepatitis B Surface Antigens
antigen
Medical Schools
Italy
virus
students
Vaccination
student
Students
infancy
odds ratio
confidence interval
serum
nursing education
Biomarkers
Odds Ratio
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Waste Management and Disposal
  • Public Health, Environmental and Occupational Health

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@article{9a4a5a5a08d84f788e37a5e6603d7e23,
title = "Predictors of Hepatitis B Surface Antigen Titers two decades after vaccination in a cohort of students and post-graduates of the Medical School at the University of Palermo, Italy",
abstract = "Introduction and objective. The introduction of a vaccine against hepatitis B virus (HBV) for newborn babies in Italy in 1991, extended to 12-year-old children for the first 12 years of application, has been a major achievement in terms of theprevention of HBV infection. The objective of this study was to analyse the long-term immunogenicity and effectiveness of HBV vaccination among healthcare students with different working seniorities.Materials and method. A cross-sectional observational study of undergraduate and postgraduate students attending the Medical School of the University of Palermo was conducted from January 2014 – July 2016. HBV serum markers were performed with commercial chemiluminescence assays. Categorical variables were analyzed using the chi-square test (Mantel–Haenszel), whereas means were compared by using the Student’s t test. Adjusted odds ratios (ORs) and 95{\%} confidence intervals (CIs) were also calculated by a multivariable logistic regression, using a model constructed to examine predictors of anti-HBs titer above 10 mIU/mL, assumed as protective. Results. Of the 2,114 subjects evaluated – all vaccinated at infancy or at the age of 12 years and were HBsAg/anti-HBc negative – 806 (38.1{\%}) had an anti-HBs titre <10 IU/L. The latter were younger, more likely to be attending a healthcareprofession school (i.e., nursing and midwifery), than a medical postgraduate level school, and more likely to have been vaccinated in infancy (p <0.001, 95{\%} CI 2.63–5.26, adjusted OR 3.70).Conclusion. The results of the study suggest that assessment of HBV serum markers in workers potentially exposed to hospital infections is useful for identifying small numbers of unvaccinated subjects, or vaccinated subjects with low antibody titre, all of whom should be referred to a booster series of vaccinations.",
author = "Diego Picciotto and Emanuele Amodio and Giovanni Giammanco and Donatella Ferraro and Verso, {Maria Gabriella} and {De Grazia}, Simona and Emanuele Amodio",
year = "2017",
language = "English",
volume = "24",
pages = "303--306",
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TY - JOUR

T1 - Predictors of Hepatitis B Surface Antigen Titers two decades after vaccination in a cohort of students and post-graduates of the Medical School at the University of Palermo, Italy

AU - Picciotto, Diego

AU - Amodio, Emanuele

AU - Giammanco, Giovanni

AU - Ferraro, Donatella

AU - Verso, Maria Gabriella

AU - De Grazia, Simona

AU - Amodio, Emanuele

PY - 2017

Y1 - 2017

N2 - Introduction and objective. The introduction of a vaccine against hepatitis B virus (HBV) for newborn babies in Italy in 1991, extended to 12-year-old children for the first 12 years of application, has been a major achievement in terms of theprevention of HBV infection. The objective of this study was to analyse the long-term immunogenicity and effectiveness of HBV vaccination among healthcare students with different working seniorities.Materials and method. A cross-sectional observational study of undergraduate and postgraduate students attending the Medical School of the University of Palermo was conducted from January 2014 – July 2016. HBV serum markers were performed with commercial chemiluminescence assays. Categorical variables were analyzed using the chi-square test (Mantel–Haenszel), whereas means were compared by using the Student’s t test. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were also calculated by a multivariable logistic regression, using a model constructed to examine predictors of anti-HBs titer above 10 mIU/mL, assumed as protective. Results. Of the 2,114 subjects evaluated – all vaccinated at infancy or at the age of 12 years and were HBsAg/anti-HBc negative – 806 (38.1%) had an anti-HBs titre <10 IU/L. The latter were younger, more likely to be attending a healthcareprofession school (i.e., nursing and midwifery), than a medical postgraduate level school, and more likely to have been vaccinated in infancy (p <0.001, 95% CI 2.63–5.26, adjusted OR 3.70).Conclusion. The results of the study suggest that assessment of HBV serum markers in workers potentially exposed to hospital infections is useful for identifying small numbers of unvaccinated subjects, or vaccinated subjects with low antibody titre, all of whom should be referred to a booster series of vaccinations.

AB - Introduction and objective. The introduction of a vaccine against hepatitis B virus (HBV) for newborn babies in Italy in 1991, extended to 12-year-old children for the first 12 years of application, has been a major achievement in terms of theprevention of HBV infection. The objective of this study was to analyse the long-term immunogenicity and effectiveness of HBV vaccination among healthcare students with different working seniorities.Materials and method. A cross-sectional observational study of undergraduate and postgraduate students attending the Medical School of the University of Palermo was conducted from January 2014 – July 2016. HBV serum markers were performed with commercial chemiluminescence assays. Categorical variables were analyzed using the chi-square test (Mantel–Haenszel), whereas means were compared by using the Student’s t test. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were also calculated by a multivariable logistic regression, using a model constructed to examine predictors of anti-HBs titer above 10 mIU/mL, assumed as protective. Results. Of the 2,114 subjects evaluated – all vaccinated at infancy or at the age of 12 years and were HBsAg/anti-HBc negative – 806 (38.1%) had an anti-HBs titre <10 IU/L. The latter were younger, more likely to be attending a healthcareprofession school (i.e., nursing and midwifery), than a medical postgraduate level school, and more likely to have been vaccinated in infancy (p <0.001, 95% CI 2.63–5.26, adjusted OR 3.70).Conclusion. The results of the study suggest that assessment of HBV serum markers in workers potentially exposed to hospital infections is useful for identifying small numbers of unvaccinated subjects, or vaccinated subjects with low antibody titre, all of whom should be referred to a booster series of vaccinations.

UR - http://hdl.handle.net/10447/237134

UR - http://www.aaem.pl/Predictors-of-Hepatitis-B-Surface-Antigen-Titers-two-decades-after-vaccination-in-a-cohort-of-students-and-post-graduates-of-the-Medical-nSchool-at-the-University-of-Palermo-Italy,74716,0,2.html

M3 - Article

VL - 24

SP - 303

EP - 306

JO - Default journal

JF - Default journal

ER -