TY - JOUR
T1 - Predictive and Prognostic Molecular Factors in Diffuse Large B-Cell Lymphomas
AU - Tripodo, Claudio
AU - Derenzini, Enrico
AU - Ciavarella, Sabino
AU - Mazzara, Saveria
AU - Tabanelli, Valentina
AU - Vegliante, Maria Carmela
AU - Pileri, Stefano A.
AU - Melle, Federica
AU - Fiori, Stefano
AU - Fiori, Stefano
AU - Pileri, Stefano A.
AU - Tripodo, Claudio
AU - Motta, Giovanna
PY - 2021
Y1 - 2021
N2 - Diffuse large B-cell lymphoma (DLBCL) is the commonest form of lymphoid malignancy, with a prevalence of about 40% worldwide. Its classification encompasses a common form, also termed as "not otherwise specified" (NOS), and a series of variants, which are rare and at least in part related to viral agents. Over the last two decades, DLBCL-NOS, which accounts for more than 80% of the neoplasms included in the DLBCL chapter, has been the object of an increasing number of molecular studies which have led to the identification of prognostic/predictive factors that are increasingly entering daily practice. In this review, the main achievements obtained by gene expression profiling (with respect to both neoplastic cells and the microenvironment) and next-generation sequencing will be discussed and compared. Only the amalgamation of molecular attributes will lead to the achievement of the long-term goal of using tailored therapies and possibly chemotherapy-free protocols capable of curing most (if not all) patients with minimal or no toxic effects.
AB - Diffuse large B-cell lymphoma (DLBCL) is the commonest form of lymphoid malignancy, with a prevalence of about 40% worldwide. Its classification encompasses a common form, also termed as "not otherwise specified" (NOS), and a series of variants, which are rare and at least in part related to viral agents. Over the last two decades, DLBCL-NOS, which accounts for more than 80% of the neoplasms included in the DLBCL chapter, has been the object of an increasing number of molecular studies which have led to the identification of prognostic/predictive factors that are increasingly entering daily practice. In this review, the main achievements obtained by gene expression profiling (with respect to both neoplastic cells and the microenvironment) and next-generation sequencing will be discussed and compared. Only the amalgamation of molecular attributes will lead to the achievement of the long-term goal of using tailored therapies and possibly chemotherapy-free protocols capable of curing most (if not all) patients with minimal or no toxic effects.
UR - http://hdl.handle.net/10447/510045
M3 - Article
VL - 10
SP - 675-
JO - Cells
JF - Cells
SN - 2073-4409
ER -