Prediction of unfavorable outcomes in West Nile virus neuroinvasive infection – Result of a multinational ID-IRI study

Antonio Cascio, Husnu Pullukcu, Corneliu Petru Popescu, Mihaela Florentina Zaharia, Yasemin Cag, Ami Neuberger, Botond Lakatos, Serkan Oncu, Hasip Kahraman, Simin Aysel Florescu, Gorana Dragovac, Daniel Codreanu, Ilaria Coledan, Mirjana Strbac, Rodrigo Hasbun, Jelena Djekic Malbasa, Natalia Pshenichnaya, Olga Shmaylenko, Éva Nagy, Razi EvendarHakan Erdem, Galina Gopatsa, Nenad Pandak, Selma Tosun, Emanoil Ceausu, Simona Maria Ruta, Arjan Harxhi

Risultato della ricerca: Article

Abstract

Background: WNV causes 1.4% of all central nervous system infections and is the most common cause of epidemic neuro-invasive disease in humans. Objectives: Our main objective was to investigate retrospectively West Nile virus neuroinvasive disease (WNND) cases hospitalized during 2010–2017 and identified factors that can influence prognosis. Study design: We documented the demographic, epidemiologic, clinical and laboratory data of WNND and identified factors that can influence prognosis. The data were recruited through Infectious Diseases International Research Initiative (ID-IRI), which serves as a network for clinical researches. Results: We investigated 165 patients with WNND in 10 countries from three continents. 27 patients died and the mortality rate was 16.4%. In an univariate analysis age, congestive heart failure, neoplasm and ischemic heart disease (p < 0.001), neuropsychiatric disorders (p = 0.011), chronic hepatitis (p = 0.024) and hypertension (p = 0.043) were risk factors for death. Fatal evolution was also correlated with ICU addmission, disorientation, speech disorders, change in consciousnes, coma, a low Glasgow coma score, obtundation, confusion (p < 0.001), history of syncope (p = 0.002) and history of unconsciousness (p = 0.037). In a binomial logistic regresssion analysis only age and coma remained independent prediction factors for death. We created an equation that was calculated according to age, co-morbidities and clinical manifestations that may be used to establish the prognosis of WNND patients. Conclusions: WNND remain an important factor for morbidity and mortality worldwide, evolution to death or survival with sequelae are not rare. Our study creates an equation that may be used in the future to establish the prognosis of WNND patients.
Lingua originaleEnglish
pagine (da-a)104213-
Numero di pagine6
RivistaJOURNAL OF CLINICAL VIROLOGY
Volume122
Stato di pubblicazionePublished - 2020

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West Nile virus
Virus Diseases
Communicable Diseases
Coma
Research
Morbidity
Speech Disorders
Central Nervous System Infections
Heart Neoplasms
Unconsciousness
Mortality
Syncope
Chronic Hepatitis
Myocardial Ischemia
Heart Failure
Demography
Hypertension
Survival

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cita questo

Cascio, A., Pullukcu, H., Popescu, C. P., Zaharia, M. F., Cag, Y., Neuberger, A., ... Harxhi, A. (2020). Prediction of unfavorable outcomes in West Nile virus neuroinvasive infection – Result of a multinational ID-IRI study. JOURNAL OF CLINICAL VIROLOGY, 122, 104213-.

Prediction of unfavorable outcomes in West Nile virus neuroinvasive infection – Result of a multinational ID-IRI study. / Cascio, Antonio; Pullukcu, Husnu; Popescu, Corneliu Petru; Zaharia, Mihaela Florentina; Cag, Yasemin; Neuberger, Ami; Lakatos, Botond; Oncu, Serkan; Kahraman, Hasip; Florescu, Simin Aysel; Dragovac, Gorana; Codreanu, Daniel; Coledan, Ilaria; Strbac, Mirjana; Hasbun, Rodrigo; Malbasa, Jelena Djekic; Pshenichnaya, Natalia; Shmaylenko, Olga; Nagy, Éva; Evendar, Razi; Erdem, Hakan; Gopatsa, Galina; Pandak, Nenad; Tosun, Selma; Ceausu, Emanoil; Ruta, Simona Maria; Harxhi, Arjan.

In: JOURNAL OF CLINICAL VIROLOGY, Vol. 122, 2020, pag. 104213-.

Risultato della ricerca: Article

Cascio, A, Pullukcu, H, Popescu, CP, Zaharia, MF, Cag, Y, Neuberger, A, Lakatos, B, Oncu, S, Kahraman, H, Florescu, SA, Dragovac, G, Codreanu, D, Coledan, I, Strbac, M, Hasbun, R, Malbasa, JD, Pshenichnaya, N, Shmaylenko, O, Nagy, É, Evendar, R, Erdem, H, Gopatsa, G, Pandak, N, Tosun, S, Ceausu, E, Ruta, SM & Harxhi, A 2020, 'Prediction of unfavorable outcomes in West Nile virus neuroinvasive infection – Result of a multinational ID-IRI study', JOURNAL OF CLINICAL VIROLOGY, vol. 122, pagg. 104213-.
Cascio, Antonio ; Pullukcu, Husnu ; Popescu, Corneliu Petru ; Zaharia, Mihaela Florentina ; Cag, Yasemin ; Neuberger, Ami ; Lakatos, Botond ; Oncu, Serkan ; Kahraman, Hasip ; Florescu, Simin Aysel ; Dragovac, Gorana ; Codreanu, Daniel ; Coledan, Ilaria ; Strbac, Mirjana ; Hasbun, Rodrigo ; Malbasa, Jelena Djekic ; Pshenichnaya, Natalia ; Shmaylenko, Olga ; Nagy, Éva ; Evendar, Razi ; Erdem, Hakan ; Gopatsa, Galina ; Pandak, Nenad ; Tosun, Selma ; Ceausu, Emanoil ; Ruta, Simona Maria ; Harxhi, Arjan. / Prediction of unfavorable outcomes in West Nile virus neuroinvasive infection – Result of a multinational ID-IRI study. In: JOURNAL OF CLINICAL VIROLOGY. 2020 ; Vol. 122. pagg. 104213-.
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title = "Prediction of unfavorable outcomes in West Nile virus neuroinvasive infection – Result of a multinational ID-IRI study",
abstract = "Background: WNV causes 1.4{\%} of all central nervous system infections and is the most common cause of epidemic neuro-invasive disease in humans. Objectives: Our main objective was to investigate retrospectively West Nile virus neuroinvasive disease (WNND) cases hospitalized during 2010–2017 and identified factors that can influence prognosis. Study design: We documented the demographic, epidemiologic, clinical and laboratory data of WNND and identified factors that can influence prognosis. The data were recruited through Infectious Diseases International Research Initiative (ID-IRI), which serves as a network for clinical researches. Results: We investigated 165 patients with WNND in 10 countries from three continents. 27 patients died and the mortality rate was 16.4{\%}. In an univariate analysis age, congestive heart failure, neoplasm and ischemic heart disease (p < 0.001), neuropsychiatric disorders (p = 0.011), chronic hepatitis (p = 0.024) and hypertension (p = 0.043) were risk factors for death. Fatal evolution was also correlated with ICU addmission, disorientation, speech disorders, change in consciousnes, coma, a low Glasgow coma score, obtundation, confusion (p < 0.001), history of syncope (p = 0.002) and history of unconsciousness (p = 0.037). In a binomial logistic regresssion analysis only age and coma remained independent prediction factors for death. We created an equation that was calculated according to age, co-morbidities and clinical manifestations that may be used to establish the prognosis of WNND patients. Conclusions: WNND remain an important factor for morbidity and mortality worldwide, evolution to death or survival with sequelae are not rare. Our study creates an equation that may be used in the future to establish the prognosis of WNND patients.",
keywords = "Death, Encephalitis, Meningitis, Neuroinvasive, WNV, West Nile virus",
author = "Antonio Cascio and Husnu Pullukcu and Popescu, {Corneliu Petru} and Zaharia, {Mihaela Florentina} and Yasemin Cag and Ami Neuberger and Botond Lakatos and Serkan Oncu and Hasip Kahraman and Florescu, {Simin Aysel} and Gorana Dragovac and Daniel Codreanu and Ilaria Coledan and Mirjana Strbac and Rodrigo Hasbun and Malbasa, {Jelena Djekic} and Natalia Pshenichnaya and Olga Shmaylenko and {\'E}va Nagy and Razi Evendar and Hakan Erdem and Galina Gopatsa and Nenad Pandak and Selma Tosun and Emanoil Ceausu and Ruta, {Simona Maria} and Arjan Harxhi",
year = "2020",
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volume = "122",
pages = "104213--",
journal = "JOURNAL OF CLINICAL VIROLOGY",
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TY - JOUR

T1 - Prediction of unfavorable outcomes in West Nile virus neuroinvasive infection – Result of a multinational ID-IRI study

AU - Cascio, Antonio

AU - Pullukcu, Husnu

AU - Popescu, Corneliu Petru

AU - Zaharia, Mihaela Florentina

AU - Cag, Yasemin

AU - Neuberger, Ami

AU - Lakatos, Botond

AU - Oncu, Serkan

AU - Kahraman, Hasip

AU - Florescu, Simin Aysel

AU - Dragovac, Gorana

AU - Codreanu, Daniel

AU - Coledan, Ilaria

AU - Strbac, Mirjana

AU - Hasbun, Rodrigo

AU - Malbasa, Jelena Djekic

AU - Pshenichnaya, Natalia

AU - Shmaylenko, Olga

AU - Nagy, Éva

AU - Evendar, Razi

AU - Erdem, Hakan

AU - Gopatsa, Galina

AU - Pandak, Nenad

AU - Tosun, Selma

AU - Ceausu, Emanoil

AU - Ruta, Simona Maria

AU - Harxhi, Arjan

PY - 2020

Y1 - 2020

N2 - Background: WNV causes 1.4% of all central nervous system infections and is the most common cause of epidemic neuro-invasive disease in humans. Objectives: Our main objective was to investigate retrospectively West Nile virus neuroinvasive disease (WNND) cases hospitalized during 2010–2017 and identified factors that can influence prognosis. Study design: We documented the demographic, epidemiologic, clinical and laboratory data of WNND and identified factors that can influence prognosis. The data were recruited through Infectious Diseases International Research Initiative (ID-IRI), which serves as a network for clinical researches. Results: We investigated 165 patients with WNND in 10 countries from three continents. 27 patients died and the mortality rate was 16.4%. In an univariate analysis age, congestive heart failure, neoplasm and ischemic heart disease (p < 0.001), neuropsychiatric disorders (p = 0.011), chronic hepatitis (p = 0.024) and hypertension (p = 0.043) were risk factors for death. Fatal evolution was also correlated with ICU addmission, disorientation, speech disorders, change in consciousnes, coma, a low Glasgow coma score, obtundation, confusion (p < 0.001), history of syncope (p = 0.002) and history of unconsciousness (p = 0.037). In a binomial logistic regresssion analysis only age and coma remained independent prediction factors for death. We created an equation that was calculated according to age, co-morbidities and clinical manifestations that may be used to establish the prognosis of WNND patients. Conclusions: WNND remain an important factor for morbidity and mortality worldwide, evolution to death or survival with sequelae are not rare. Our study creates an equation that may be used in the future to establish the prognosis of WNND patients.

AB - Background: WNV causes 1.4% of all central nervous system infections and is the most common cause of epidemic neuro-invasive disease in humans. Objectives: Our main objective was to investigate retrospectively West Nile virus neuroinvasive disease (WNND) cases hospitalized during 2010–2017 and identified factors that can influence prognosis. Study design: We documented the demographic, epidemiologic, clinical and laboratory data of WNND and identified factors that can influence prognosis. The data were recruited through Infectious Diseases International Research Initiative (ID-IRI), which serves as a network for clinical researches. Results: We investigated 165 patients with WNND in 10 countries from three continents. 27 patients died and the mortality rate was 16.4%. In an univariate analysis age, congestive heart failure, neoplasm and ischemic heart disease (p < 0.001), neuropsychiatric disorders (p = 0.011), chronic hepatitis (p = 0.024) and hypertension (p = 0.043) were risk factors for death. Fatal evolution was also correlated with ICU addmission, disorientation, speech disorders, change in consciousnes, coma, a low Glasgow coma score, obtundation, confusion (p < 0.001), history of syncope (p = 0.002) and history of unconsciousness (p = 0.037). In a binomial logistic regresssion analysis only age and coma remained independent prediction factors for death. We created an equation that was calculated according to age, co-morbidities and clinical manifestations that may be used to establish the prognosis of WNND patients. Conclusions: WNND remain an important factor for morbidity and mortality worldwide, evolution to death or survival with sequelae are not rare. Our study creates an equation that may be used in the future to establish the prognosis of WNND patients.

KW - Death

KW - Encephalitis

KW - Meningitis

KW - Neuroinvasive

KW - WNV

KW - West Nile virus

UR - http://hdl.handle.net/10447/387324

UR - http://www.elsevier.com/inca/publications/store/5/2/4/0/6/2

M3 - Article

VL - 122

SP - 104213-

JO - JOURNAL OF CLINICAL VIROLOGY

JF - JOURNAL OF CLINICAL VIROLOGY

SN - 1386-6532

ER -