Preclinical Dementia: An Italian Multicentre Study on Amnestic Mild Cognitive Impairment

Roberto Monastero, Gallucci, Carlo Caltagirone, Alessandro Padovani, Graceffa, Carlomagno, Michele Perini, Gambina, Franceschi, Franceschi, Franceschi, Tognoni, Mina, Ghidoni, Alberoni, Bonaiuto, De Bastiani, Zagnoni, Angelo Quartarone, PettenatiLorusso, Paolo Caffarra, Roberta Perri, Bottini, Giubilei, Massimo Franceschi, Piras, Senin, Di Luca, Girotti, Carolei, Giovanni A. Carlesimo, Provinciali, Enzo Grossi, Laura Serra, Appollonio, Rita Savarè, Marchetti

Risultato della ricerca: Articlepeer review

38 Citazioni (Scopus)


Background: Different rates and cognitive predictors ofconversion to dementia have been reported in subjects withdifferent kinds of mild cognitive impairment (MCI). Methods:A prospective, 24-month follow-up study, involving 269subjects who strictly fulfilled criteria for the amnestic MCI.Results: Conversion rate to dementia was 21.4% per year.Seventy-nine out of the 83 individuals who developed dementiawere affected by probable Alzheimer’s disease (AD).Among others, at the 24-month follow-up 24.1% were stillaffected by amnestic MCI, 13.3% had changed their neuropsychologicalprofile of impairment and 17.2% were cognitivelynormalised. Compared to subjects who did not convertto AD, those who did convert showed poorer immediateand delayed recall and recognition of verbal and visual materialat baseline as well as reduced executive abilities. Acombination of age, Clinical Dementia Rating boxes andscores on delayed recall and recognition of verbal and visualmaterial accurately identified 86% of the subjects who developedAD. Conclusions: Elderly subjects affected by anisolated memory disorder have a high probability of developing AD. The ability of verbal and visual measures to predictincipient dementia of memory impairment may be increasedby the simultaneous assessment of individualfeatures, such as age or rate of functional impairment.
Lingua originaleEnglish
pagine (da-a)289-300
Numero di pagine12
RivistaDementia and Geriatric Cognitive Disorders
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

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