POUCHITIS: A TRIDIMENSIONAL VIEW

Francesco Cappello, Giovanni Tomasello, Francesco Carini, Salvatore Marasà, Dario Raimondo, Giancarlo Pompei, Aroldo Gabriele Rizzo, Emanuele Sinagra, Guido Martorana, Francesca Rossi, Stefano Mandalà, Giovanni Tomasello, Pier Enrico Marchesa, Francesco Cappello

Risultato della ricerca: Article

Abstract

The preferred surgical treatment of ulcerative colitis (UC) and familial adenomatous polyposis (FAP) is represented by proctocolectomy with ileal pouch-anal anastomosis (IPAA). However, patients with UYC who have undergone IPAA are prone to develop several complications, which include surgery related/mecchanical complications; inflammatory or infectious disoreders; dysplasia or neoplasia; and systemic or metabolic disorders. Pouchitis, which is defined as the acute and/or chronic inflammation of the ileal reservoir, represent the most common long-term adverese sequela after IPAA. Gut microbiota play a pivotal role in the initiation and disease progression of pouchitis. Pouchitis can be classified according to the activity of the disease, the duration of the symptoms, the pattern of the disease or response to antibiotic therapy. Patients with IPAA for UC tend to experience a variety of symptoms that may eventually lead to pouch excision thereby necessitating the construction of a permanent ileostomy. To date, the ethiology, the diagnosis and the medical management of pouchitis represent a clinical challenge. In fact pouchitis range from a disease with an acute antibiotic-responsive presentation to a chronic antibiotic-refractory form, with subsequent different disease mechanism and clinical course. A tridimensional and multidisciplinar approach, including endoscopy, histology, and laboratory testing is widely helpful to identify the diferent phenotypes of the disease and to manage correctly its treatment.
Lingua originaleEnglish
pagine (da-a)315-322
Numero di pagine8
RivistaDefault journal
Volume18
Stato di pubblicazionePublished - 2016

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Pouchitis
Colonic Pouches
pouches
antibiotics
colitis
Anti-Bacterial Agents
Ulcerative Colitis
disease course
signs and symptoms (animals and humans)
Ileostomy
Adenomatous Polyposis Coli
endoscopy
complications (disease)
metabolic diseases
Acute Disease
intestinal microorganisms
histology
Endoscopy
Disease Progression
Histology

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cita questo

Cappello, F., Tomasello, G., Carini, F., Marasà, S., Raimondo, D., Pompei, G., ... Cappello, F. (2016). POUCHITIS: A TRIDIMENSIONAL VIEW. Default journal, 18, 315-322.

POUCHITIS: A TRIDIMENSIONAL VIEW. / Cappello, Francesco; Tomasello, Giovanni; Carini, Francesco; Marasà, Salvatore; Raimondo, Dario; Pompei, Giancarlo; Rizzo, Aroldo Gabriele; Sinagra, Emanuele; Martorana, Guido; Rossi, Francesca; Mandalà, Stefano; Tomasello, Giovanni; Marchesa, Pier Enrico; Cappello, Francesco.

In: Default journal, Vol. 18, 2016, pag. 315-322.

Risultato della ricerca: Article

Cappello, F, Tomasello, G, Carini, F, Marasà, S, Raimondo, D, Pompei, G, Rizzo, AG, Sinagra, E, Martorana, G, Rossi, F, Mandalà, S, Tomasello, G, Marchesa, PE & Cappello, F 2016, 'POUCHITIS: A TRIDIMENSIONAL VIEW', Default journal, vol. 18, pagg. 315-322.
Cappello F, Tomasello G, Carini F, Marasà S, Raimondo D, Pompei G e altri. POUCHITIS: A TRIDIMENSIONAL VIEW. Default journal. 2016;18:315-322.
Cappello, Francesco ; Tomasello, Giovanni ; Carini, Francesco ; Marasà, Salvatore ; Raimondo, Dario ; Pompei, Giancarlo ; Rizzo, Aroldo Gabriele ; Sinagra, Emanuele ; Martorana, Guido ; Rossi, Francesca ; Mandalà, Stefano ; Tomasello, Giovanni ; Marchesa, Pier Enrico ; Cappello, Francesco. / POUCHITIS: A TRIDIMENSIONAL VIEW. In: Default journal. 2016 ; Vol. 18. pagg. 315-322.
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abstract = "The preferred surgical treatment of ulcerative colitis (UC) and familial adenomatous polyposis (FAP) is represented by proctocolectomy with ileal pouch-anal anastomosis (IPAA). However, patients with UYC who have undergone IPAA are prone to develop several complications, which include surgery related/mecchanical complications; inflammatory or infectious disoreders; dysplasia or neoplasia; and systemic or metabolic disorders. Pouchitis, which is defined as the acute and/or chronic inflammation of the ileal reservoir, represent the most common long-term adverese sequela after IPAA. Gut microbiota play a pivotal role in the initiation and disease progression of pouchitis. Pouchitis can be classified according to the activity of the disease, the duration of the symptoms, the pattern of the disease or response to antibiotic therapy. Patients with IPAA for UC tend to experience a variety of symptoms that may eventually lead to pouch excision thereby necessitating the construction of a permanent ileostomy. To date, the ethiology, the diagnosis and the medical management of pouchitis represent a clinical challenge. In fact pouchitis range from a disease with an acute antibiotic-responsive presentation to a chronic antibiotic-refractory form, with subsequent different disease mechanism and clinical course. A tridimensional and multidisciplinar approach, including endoscopy, histology, and laboratory testing is widely helpful to identify the diferent phenotypes of the disease and to manage correctly its treatment.",
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AU - Tomasello, Giovanni

AU - Carini, Francesco

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AU - Raimondo, Dario

AU - Pompei, Giancarlo

AU - Rizzo, Aroldo Gabriele

AU - Sinagra, Emanuele

AU - Martorana, Guido

AU - Rossi, Francesca

AU - Mandalà, Stefano

AU - Tomasello, Giovanni

AU - Marchesa, Pier Enrico

AU - Cappello, Francesco

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