Potential role of the natural multi-targeted agent curcumin in the treatment of oral diseases.

Risultato della ricerca: Article

Abstract

We critically review the current data on the therapeutic effects and basic biological activities of the natural compound curcumin on various oral diseases: a sound experimental evidence appears to support its possible use against relevant pathologies which include cancer, radiotherapy- and chemotherapy-induced mucositis, lichen planus and periodontitis. This versatility of curcumin depends on its ability of interacting with multiple targets, though inhibition of the transcription factor NF-kB can be identified as one of the principal mechanisms. The therapeutic potentialities of curcumin in oral medicine have, however, to be further verified, in particular by more human ad hoc in vivo studies. An important aspect that remains to resolve is that of improving by adequate approaches the topical or systemic delivery of the drug to the target tissues. At present there is also a very active search for the synthesis of new curcumin derivatives endowed with improved pharmacokinetic and pharmacodynamic characteristics.
Lingua originaleEnglish
pagine (da-a)135-146
Numero di pagine12
RivistaInternational Journal of Clinical Dentistry
Volume2
Stato di pubblicazionePublished - 2009

Fingerprint

Mouth Diseases
Curcumin
Oral Medicine
Lichen Planus
Mucositis
NF-kappa B
Periodontitis
Therapeutic Uses
Therapeutics
Radiotherapy
Pharmacokinetics
Pathology
Drug Therapy
Pharmaceutical Preparations
Neoplasms

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cita questo

@article{aafa1c7b54c343478534895844584bc6,
title = "Potential role of the natural multi-targeted agent curcumin in the treatment of oral diseases.",
abstract = "We critically review the current data on the therapeutic effects and basic biological activities of the natural compound curcumin on various oral diseases: a sound experimental evidence appears to support its possible use against relevant pathologies which include cancer, radiotherapy- and chemotherapy-induced mucositis, lichen planus and periodontitis. This versatility of curcumin depends on its ability of interacting with multiple targets, though inhibition of the transcription factor NF-kB can be identified as one of the principal mechanisms. The therapeutic potentialities of curcumin in oral medicine have, however, to be further verified, in particular by more human ad hoc in vivo studies. An important aspect that remains to resolve is that of improving by adequate approaches the topical or systemic delivery of the drug to the target tissues. At present there is also a very active search for the synthesis of new curcumin derivatives endowed with improved pharmacokinetic and pharmacodynamic characteristics.",
keywords = "Curcumin, Multi-targeted agent, Oral cancer, Mucositis, Periodontitis, Oral lichen planus, NF-kB",
author = "Natale D'Alessandro and Manuela Labbozzetta",
year = "2009",
language = "English",
volume = "2",
pages = "135--146",
journal = "International Journal of Clinical Dentistry",
issn = "1939-5833",
publisher = "Nova Science Publishers Inc",

}

TY - JOUR

T1 - Potential role of the natural multi-targeted agent curcumin in the treatment of oral diseases.

AU - D'Alessandro, Natale

AU - Labbozzetta, Manuela

PY - 2009

Y1 - 2009

N2 - We critically review the current data on the therapeutic effects and basic biological activities of the natural compound curcumin on various oral diseases: a sound experimental evidence appears to support its possible use against relevant pathologies which include cancer, radiotherapy- and chemotherapy-induced mucositis, lichen planus and periodontitis. This versatility of curcumin depends on its ability of interacting with multiple targets, though inhibition of the transcription factor NF-kB can be identified as one of the principal mechanisms. The therapeutic potentialities of curcumin in oral medicine have, however, to be further verified, in particular by more human ad hoc in vivo studies. An important aspect that remains to resolve is that of improving by adequate approaches the topical or systemic delivery of the drug to the target tissues. At present there is also a very active search for the synthesis of new curcumin derivatives endowed with improved pharmacokinetic and pharmacodynamic characteristics.

AB - We critically review the current data on the therapeutic effects and basic biological activities of the natural compound curcumin on various oral diseases: a sound experimental evidence appears to support its possible use against relevant pathologies which include cancer, radiotherapy- and chemotherapy-induced mucositis, lichen planus and periodontitis. This versatility of curcumin depends on its ability of interacting with multiple targets, though inhibition of the transcription factor NF-kB can be identified as one of the principal mechanisms. The therapeutic potentialities of curcumin in oral medicine have, however, to be further verified, in particular by more human ad hoc in vivo studies. An important aspect that remains to resolve is that of improving by adequate approaches the topical or systemic delivery of the drug to the target tissues. At present there is also a very active search for the synthesis of new curcumin derivatives endowed with improved pharmacokinetic and pharmacodynamic characteristics.

KW - Curcumin, Multi-targeted agent, Oral cancer, Mucositis, Periodontitis, Oral lichen planus, NF-kB

UR - http://hdl.handle.net/10447/37825

M3 - Article

VL - 2

SP - 135

EP - 146

JO - International Journal of Clinical Dentistry

JF - International Journal of Clinical Dentistry

SN - 1939-5833

ER -