Potential Effect of Antiplatelet and Anticoagulant Therapy on the Timing of the Diagnosis of Bladder Cancer

Vincenzo Serretta, Lorenzo Rocchini, Federico Pellucchi, Marco Moschini, Nazareno Suardi, R. Jeffrey Karnes, Andrea Salonia, Renzo Colombo, Francesco Montorsi, Rocco Damiano, Marco Bianchi, Alberto Briganti

Risultato della ricerca: Articlepeer review

5 Citazioni (Scopus)


Background: The most common presenting symptom of bladder cancer (BCa) is hematuria. The present study was designed to define whether patients taking antiplatelet and/or anticoagulant drugs might experience hematuria at an earlier stage or grade of BCa. Patients and Methods: The data from 1532 consecutive patients who presented to the emergency unit of our institute from 2004 to 2012 because of gross hematuria as a single symptom were evaluated. Patients (n= 227) with a further diagnosis of BCa were included in our study. For the purpose of the present study, patients were divided into 2 groups: patients receiving antiplatelet or anticoagulant therapy (AAT) (group 1) and patients not receiving AAT (group 2) at the moment of the macroscopic hematuria episode. The effect of AAT on the pathologic stage and grade of BCa was statistically assessed using univariate and multivariate logistic regression analysis. Results: A total of 59 (26%) and 168 (74%) patients were included in groups 1 and 2, respectively. On multivariate logistic regression analysis, ATT conferred a protective effect against both pathologic stage≥ T2 (odds ratio [OR], 0.37; 95% confidential interval [CI], 0.12-0.66; P= .01) and higher grade (OR, 0.56; 95% CI, 0.26-0.85; P = 02) at tumor presentation. Conclusion: According to the results of the present retrospective investigation, patients who received AAT seem to experience gross hematuria significantly earlier than do untreated patients, resulting in the chance of an earlier diagnosis and treatment of bladder cancer.
Lingua originaleEnglish
pagine (da-a)245-250
Numero di pagine6
RivistaClinical Genitourinary Cancer
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2730???
  • ???subjectarea.asjc.2700.2748???


Entra nei temi di ricerca di 'Potential Effect of Antiplatelet and Anticoagulant Therapy on the Timing of the Diagnosis of Bladder Cancer'. Insieme formano una fingerprint unica.

Cita questo