Potential drug-drug interaction between duloxetine and acenocoumarol in a patientwith Alzheimer's disease

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16 Citazioni (Scopus)

Abstract

ABSTRACTBackground: Recent evidence suggests that duloxetine may increase the effect of warfarin, thereby increasingthe possibility of bleeding. However, a MEDLINE search for articles published between 1980 and May 2007(terms: duloxetine, anticoagulants, acenocoumarol, and interaction; no language restriction) did not yield anyreports of an interaction between concomitant use of duloxetine and acenocoumarol. Objective: The aim of this study was to describe a potential drug–drug interaction between duloxetineand acenocoumarol in a patient with Alzheimer’s disease. The possible mechanism of this potential interaction is examined.Case summary: This report presents the case of a 63-year-old white female patient weighing 64 kg receiving oral treatment with the synthetic coumarinanticoagulant acenocoumarol (mean dosage, 9 mg/wk) for 8 years who experienced a persistent (3-week) decrease in international normalized ratio (INR) to 1.49after taking a single 60-mg dose of duloxetine. Three weeks after discontinuation of duloxetine, the INR returned to the previous baseline level (2.58).Conclusions: This case report suggests a possible drug–drug interaction between duloxetine and acenocoumarol. Duloxetine should be administered withcaution in patients receiving acenocoumarol therapy.
Lingua originaleEnglish
pagine (da-a)2706-2709
Numero di pagine4
RivistaClinical Therapeutics
Volume29
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2736???

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