Possible role of ABO system in age-related diseases and longevity: a narrative review

Calogero Caruso, Claudia Maria Rizzo, Sonya Vasto, Calogero Caruso, Sonya Vasto, Claudia Rizzo

Risultato della ricerca: Article

9 Citazioni (Scopus)

Abstract

ABO blood group antigens are expressed either on the surface of red blood cells either on a variety of other cells. Based on the available knowledge of the genes involved in their biosynthesis and their tissue distribution, their polymorphism has been suggested to provide intraspecies diversity allowing to cope with diverse and rapidly evolving pathogens. Accordingly, the different prevalence of ABO group genotypes among the populations has been demonstrated to be driven by malaria selection. In the similar manner, a particular ABO blood group may contribute to favour life-extension via biological mechanisms important for surviving or eluding serious disease. In this review, we will suggest the possible association of ABO group with age-related diseases and longevity taking into account the biological role of the ABO glycosyltransferases on some inflammatory mediators as adhesion molecules
Lingua originaleEnglish
pagine (da-a)-
Numero di pagine0
RivistaIMMUNITY & AGEING
Volume11
Stato di pubblicazionePublished - 2014

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Blood Group Antigens
Glycosyltransferases
Tissue Distribution
Life Expectancy
Malaria
Age Groups
Erythrocytes
Genotype
Population
Genes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Ageing

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Possible role of ABO system in age-related diseases and longevity: a narrative review. / Caruso, Calogero; Rizzo, Claudia Maria; Vasto, Sonya; Caruso, Calogero; Vasto, Sonya; Rizzo, Claudia.

In: IMMUNITY & AGEING, Vol. 11, 2014, pag. -.

Risultato della ricerca: Article

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AU - Rizzo, Claudia Maria

AU - Vasto, Sonya

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AU - Vasto, Sonya

AU - Rizzo, Claudia

PY - 2014

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AB - ABO blood group antigens are expressed either on the surface of red blood cells either on a variety of other cells. Based on the available knowledge of the genes involved in their biosynthesis and their tissue distribution, their polymorphism has been suggested to provide intraspecies diversity allowing to cope with diverse and rapidly evolving pathogens. Accordingly, the different prevalence of ABO group genotypes among the populations has been demonstrated to be driven by malaria selection. In the similar manner, a particular ABO blood group may contribute to favour life-extension via biological mechanisms important for surviving or eluding serious disease. In this review, we will suggest the possible association of ABO group with age-related diseases and longevity taking into account the biological role of the ABO glycosyltransferases on some inflammatory mediators as adhesion molecules

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