Portraying infective endocarditis: results of multinational ID-IRI study

Antonio Cascio; Deborah Konopnicki; Lurdes Santos; Alper Sener; Gilda Tonziello; Sukran Kose; Corneliu Popescu; Nefise Oztoprak; Fahad Almajid; Guven Celebi; Derya Ozturk-Engin; Xavier Argemi; Jamal Wadi; Meltem Avci; Nicolas Dauby; Yasemin Cag; Ilkay Bozkurt; Recep Tekin; Imran Hasanoglu; Ejaz Ahmed Khan; Rahmet Guner; Fahad Almajid; Nesrin Ghanem-Zoubi; Aysegul Erdem; Edmond Puca; Ayse Kaya-Kalem; Irina Magdalena Dumitru; Meliha Meric-Koc; Hacer Deniz Ozkaya; André Silva-Pinto; Ayse Sagmak-Tartar; Meltem Tasbakan; Abdullah Umut Pekok; Ayse Kaya-Kalem; Serkan Oncu; Jesper Damsgaard Gunst; Rosa Fontana Del Vecchio; Guven Celebi; Simin Florescu; Yvon Ruch; Safak Ozer-Balin; Raquel Duro; Safak Ozer-Balin; Mustafa Dogan; Nicola Petrosillo; Corneliu Popescu; Sema Sari; Sumeyra Karakus; Tatjana Lejko Zupanc; Arjeta Dedej; Oday Abu Ajamieh; Necla Tulek; Sema Sari; Pedro Palma Martins; Jamal Wadi; Ilker Inanc Balkan; Gilda Tonziello; Fatma Sirmatel; Nicola Petrosillo; Najada Como; Ayse Batirel; Canan Agalar; Necla Tulek; Selma Tosun; Fatma Sirmatel; Atilla Iyisoy; Jean-Philippe Mazzucotelli; Yves Hansmann; Gulden Ersoz; Nicola Petrosillo; Hakan Erdem; Pedro Palma Martins; Meliha Meric-Koc; Serda Gulsun; Asuman Inan

Portraying infective endocarditis: results of multinational ID-IRI study

Antonio Cascio, Deborah Konopnicki, Lurdes Santos, Alper Sener, Gilda Tonziello, Sukran Kose, Corneliu Popescu, Nefise Oztoprak, Fahad Almajid, Guven Celebi, Derya Ozturk-Engin, Xavier Argemi, Jamal Wadi, Meltem Avci, Nicolas Dauby, Yasemin Cag, Ilkay Bozkurt, Recep Tekin, Imran Hasanoglu, Ejaz Ahmed KhanRahmet Guner, Fahad Almajid, Nesrin Ghanem-Zoubi, Aysegul Erdem, Edmond Puca, Ayse Kaya-Kalem, Irina Magdalena Dumitru, Meliha Meric-Koc, Hacer Deniz Ozkaya, André Silva-Pinto, Ayse Sagmak-Tartar, Meltem Tasbakan, Abdullah Umut Pekok, Ayse Kaya-Kalem, Serkan Oncu, Jesper Damsgaard Gunst, Rosa Fontana Del Vecchio, Guven Celebi, Simin Florescu, Yvon Ruch, Safak Ozer-Balin, Raquel Duro, Safak Ozer-Balin, Mustafa Dogan, Nicola Petrosillo, Corneliu Popescu, Sema Sari, Sumeyra Karakus, Tatjana Lejko Zupanc, Arjeta Dedej, Oday Abu Ajamieh, Necla Tulek, Sema Sari, Pedro Palma Martins, Jamal Wadi, Ilker Inanc Balkan, Gilda Tonziello, Fatma Sirmatel, Nicola Petrosillo, Najada Como, Ayse Batirel, Canan Agalar, Necla Tulek, Selma Tosun, Fatma Sirmatel, Atilla Iyisoy, Jean-Philippe Mazzucotelli, Yves Hansmann, Gulden Ersoz, Nicola Petrosillo, Hakan Erdem, Pedro Palma Martins, Meliha Meric-Koc, Serda Gulsun, Asuman Inan

Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”

Risultato della ricerca: Article › peer review

16 Citazioni (Scopus)

Abstract

Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).

Lingua originale	English
Numero di pagine	11
Rivista	EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Stato di pubblicazione	Published - 2019

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Cascio, A., Konopnicki, D., Santos, L., Sener, A., Tonziello, G., Kose, S., Popescu, C., Oztoprak, N., Almajid, F., Celebi, G., Ozturk-Engin, D., Argemi, X., Wadi, J., Avci, M., Dauby, N., Cag, Y., Bozkurt, I., Tekin, R., Hasanoglu, I., ... Inan, A. (2019). Portraying infective endocarditis: results of multinational ID-IRI study. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES.

Cascio, A, Konopnicki, D, Santos, L, Sener, A, Tonziello, G, Kose, S, Popescu, C, Oztoprak, N, Almajid, F, Celebi, G, Ozturk-Engin, D, Argemi, X, Wadi, J, Avci, M, Dauby, N, Cag, Y, Bozkurt, I, Tekin, R, Hasanoglu, I, Khan, EA, Guner, R, Almajid, F, Ghanem-Zoubi, N, Erdem, A, Puca, E, Kaya-Kalem, A, Dumitru, IM, Meric-Koc, M, Ozkaya, HD, Silva-Pinto, A, Sagmak-Tartar, A, Tasbakan, M, Pekok, AU, Kaya-Kalem, A, Oncu, S, Gunst, JD, Del Vecchio, RF, Celebi, G, Florescu, S, Ruch, Y, Ozer-Balin, S, Duro, R, Ozer-Balin, S, Dogan, M, Petrosillo, N, Popescu, C, Sari, S, Karakus, S, Zupanc, TL, Dedej, A, Ajamieh, OA, Tulek, N, Sari, S, Martins, PP, Wadi, J, Balkan, II, Tonziello, G, Sirmatel, F, Petrosillo, N, Como, N, Batirel, A, Agalar, C, Tulek, N, Tosun, S, Sirmatel, F, Iyisoy, A, Mazzucotelli, J-P, Hansmann, Y, Ersoz, G, Petrosillo, N, Erdem, H, Martins, PP, Meric-Koc, M, Gulsun, S & Inan, A 2019, 'Portraying infective endocarditis: results of multinational ID-IRI study', EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES.

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title = "Portraying infective endocarditis: results of multinational ID-IRI study",

abstract = "Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).",

author = "Antonio Cascio and Deborah Konopnicki and Lurdes Santos and Alper Sener and Gilda Tonziello and Sukran Kose and Corneliu Popescu and Nefise Oztoprak and Fahad Almajid and Guven Celebi and Derya Ozturk-Engin and Xavier Argemi and Jamal Wadi and Meltem Avci and Nicolas Dauby and Yasemin Cag and Ilkay Bozkurt and Recep Tekin and Imran Hasanoglu and Khan, {Ejaz Ahmed} and Rahmet Guner and Fahad Almajid and Nesrin Ghanem-Zoubi and Aysegul Erdem and Edmond Puca and Ayse Kaya-Kalem and Dumitru, {Irina Magdalena} and Meliha Meric-Koc and Ozkaya, {Hacer Deniz} and Andr{\'e} Silva-Pinto and Ayse Sagmak-Tartar and Meltem Tasbakan and Pekok, {Abdullah Umut} and Ayse Kaya-Kalem and Serkan Oncu and Gunst, {Jesper Damsgaard} and {Del Vecchio}, {Rosa Fontana} and Guven Celebi and Simin Florescu and Yvon Ruch and Safak Ozer-Balin and Raquel Duro and Safak Ozer-Balin and Mustafa Dogan and Nicola Petrosillo and Corneliu Popescu and Sema Sari and Sumeyra Karakus and Zupanc, {Tatjana Lejko} and Arjeta Dedej and Ajamieh, {Oday Abu} and Necla Tulek and Sema Sari and Martins, {Pedro Palma} and Jamal Wadi and Balkan, {Ilker Inanc} and Gilda Tonziello and Fatma Sirmatel and Nicola Petrosillo and Najada Como and Ayse Batirel and Canan Agalar and Necla Tulek and Selma Tosun and Fatma Sirmatel and Atilla Iyisoy and Jean-Philippe Mazzucotelli and Yves Hansmann and Gulden Ersoz and Nicola Petrosillo and Hakan Erdem and Martins, {Pedro Palma} and Meliha Meric-Koc and Serda Gulsun and Asuman Inan",

year = "2019",

language = "English",

journal = "EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES",

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T1 - Portraying infective endocarditis: results of multinational ID-IRI study

AU - Cascio, Antonio

AU - Konopnicki, Deborah

AU - Santos, Lurdes

AU - Sener, Alper

AU - Tonziello, Gilda

AU - Kose, Sukran

AU - Popescu, Corneliu

AU - Oztoprak, Nefise

AU - Almajid, Fahad

AU - Celebi, Guven

AU - Ozturk-Engin, Derya

AU - Argemi, Xavier

AU - Wadi, Jamal

AU - Avci, Meltem

AU - Dauby, Nicolas

AU - Cag, Yasemin

AU - Bozkurt, Ilkay

AU - Tekin, Recep

AU - Hasanoglu, Imran

AU - Khan, Ejaz Ahmed

AU - Guner, Rahmet

AU - Almajid, Fahad

AU - Ghanem-Zoubi, Nesrin

AU - Erdem, Aysegul

AU - Puca, Edmond

AU - Kaya-Kalem, Ayse

AU - Dumitru, Irina Magdalena

AU - Meric-Koc, Meliha

AU - Ozkaya, Hacer Deniz

AU - Silva-Pinto, André

AU - Sagmak-Tartar, Ayse

AU - Tasbakan, Meltem

AU - Pekok, Abdullah Umut

AU - Kaya-Kalem, Ayse

AU - Oncu, Serkan

AU - Gunst, Jesper Damsgaard

AU - Del Vecchio, Rosa Fontana

AU - Celebi, Guven

AU - Florescu, Simin

AU - Ruch, Yvon

AU - Ozer-Balin, Safak

AU - Duro, Raquel

AU - Ozer-Balin, Safak

AU - Dogan, Mustafa

AU - Petrosillo, Nicola

AU - Popescu, Corneliu

AU - Sari, Sema

AU - Karakus, Sumeyra

AU - Zupanc, Tatjana Lejko

AU - Dedej, Arjeta

AU - Ajamieh, Oday Abu

AU - Tulek, Necla

AU - Sari, Sema

AU - Martins, Pedro Palma

AU - Wadi, Jamal

AU - Balkan, Ilker Inanc

AU - Tonziello, Gilda

AU - Sirmatel, Fatma

AU - Petrosillo, Nicola

AU - Como, Najada

AU - Batirel, Ayse

AU - Agalar, Canan

AU - Tulek, Necla

AU - Tosun, Selma

AU - Sirmatel, Fatma

AU - Iyisoy, Atilla

AU - Mazzucotelli, Jean-Philippe

AU - Hansmann, Yves

AU - Ersoz, Gulden

AU - Petrosillo, Nicola

AU - Erdem, Hakan

AU - Martins, Pedro Palma

AU - Meric-Koc, Meliha

AU - Gulsun, Serda

AU - Inan, Asuman

PY - 2019

Y1 - 2019

N2 - Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).

AB - Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).

UR - http://hdl.handle.net/10447/363353

M3 - Article

JO - EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

JF - EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

SN - 0934-9723

ER -

Portraying infective endocarditis: results of multinational ID-IRI study

Abstract

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