Portrait of inflammatory response to ionizing radiation treatment

Domenico Lio, Valentina Bravata', Luigi Minafra, Maria Carla Gilardi, Valentina Bravatà, Francesco Paolo Cammarata, Federica Maria Di Maggio, Giusi Irma Forte, Cristina Messa

    Risultato della ricerca: Articlepeer review

    131 Citazioni (Scopus)

    Abstract

    Ionizing radiation (IR) activates both pro-and anti-proliferative signal pathways producing an imbalance in cell fatedecision. IR is able to regulate several genes and factors involved in cell-cycle progression, survival and/or cell death,DNA repair and inflammation modulating an intracellular radiation-dependent response. Radiation therapy canmodulate anti-tumour immune responses, modifying tumour and its microenvironment. In this review, we reporthow IR could stimulate inflammatory factors to affect cell fate via multiple pathways, describing their roles on geneexpression regulation, fibrosis and invasive processes. Understanding the complex relationship between IR, inflammationand immune responses in cancer, opens up new avenues for radiation research and therapy in order to optimize andpersonalize radiation therapy treatment for each patient.
    Lingua originaleEnglish
    pagine (da-a)14-
    Numero di pagine11
    RivistaJournal of Inflammation
    Volume12
    Stato di pubblicazionePublished - 2015

    All Science Journal Classification (ASJC) codes

    • Clinical Biochemistry
    • Cell Biology

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