TY - JOUR
T1 - Polymorphisms of pro-inflammatory genes and Prostate Cancer risk: a pharmacogenomic approach.
AU - Balistreri, Carmela Rita
AU - Vasto, Sonya
AU - Caruso, Calogero
AU - Scola, Letizia
AU - Lio, Domenico
AU - Candore, Giuseppina
AU - Forte, Giusi Irma
AU - Colonna Romano, Giuseppina
AU - Vasto, Sonya
AU - Di Bona, Danilo
AU - Scola, Letizia
AU - Caruso, Calogero
AU - Listi', Florinda
PY - 2009
Y1 - 2009
N2 - In this paper, we consider the role of the genetics of inflammation in the pathophysiology of prostate cancer (PCa). This paper is not an extensive review of the literature, rather it is an expert opinion based on data from authors’ laboratories on age-related diseases and inflammation. The aim is the detection of a risk profile that potentially allows both the early identiWcation of individuals at risk for disease and the possible discovery of potential targets for medication. In fact, a major goal of clinical research is to improve early detection of age-related diseases, cancer included, by developing tools to move diagnosis backward in disease temporal course, i.e., before the clinical manifestation of the malady, where treatment might play a decisive role in preventing or significantly retarding the manifestation of the disease. The better understanding of the function and the regulation of inXammatory pathway in PCa may help to know the mechanisms of its formation and progression, as well as to identify new targets for the refinement of new treatment such as the pharmacogenomics approach.
AB - In this paper, we consider the role of the genetics of inflammation in the pathophysiology of prostate cancer (PCa). This paper is not an extensive review of the literature, rather it is an expert opinion based on data from authors’ laboratories on age-related diseases and inflammation. The aim is the detection of a risk profile that potentially allows both the early identiWcation of individuals at risk for disease and the possible discovery of potential targets for medication. In fact, a major goal of clinical research is to improve early detection of age-related diseases, cancer included, by developing tools to move diagnosis backward in disease temporal course, i.e., before the clinical manifestation of the malady, where treatment might play a decisive role in preventing or significantly retarding the manifestation of the disease. The better understanding of the function and the regulation of inXammatory pathway in PCa may help to know the mechanisms of its formation and progression, as well as to identify new targets for the refinement of new treatment such as the pharmacogenomics approach.
UR - http://hdl.handle.net/10447/46615
M3 - Article
VL - 58
SP - 1919
EP - 1933
JO - CANCER IMMUNOLOGY, IMMUNOTHERAPY
JF - CANCER IMMUNOLOGY, IMMUNOTHERAPY
SN - 0340-7004
ER -