Polymorphisms of pro-inflammatory genes and Prostate Cancer risk: a pharmacogenomic approach.

Carmela Rita Balistreri, Sonya Vasto, Calogero Caruso, Letizia Scola, Domenico Lio, Giuseppina Candore, Giusi Irma Forte, Giuseppina Colonna Romano, Sonya Vasto, Danilo Di Bona, Letizia Scola, Calogero Caruso, Florinda Listi'

Risultato della ricerca: Articlepeer review

35 Citazioni (Scopus)

Abstract

In this paper, we consider the role of the genetics of inflammation in the pathophysiology of prostate cancer (PCa). This paper is not an extensive review of the literature, rather it is an expert opinion based on data from authors’ laboratories on age-related diseases and inflammation. The aim is the detection of a risk profile that potentially allows both the early identiWcation of individuals at risk for disease and the possible discovery of potential targets for medication. In fact, a major goal of clinical research is to improve early detection of age-related diseases, cancer included, by developing tools to move diagnosis backward in disease temporal course, i.e., before the clinical manifestation of the malady, where treatment might play a decisive role in preventing or significantly retarding the manifestation of the disease. The better understanding of the function and the regulation of inXammatory pathway in PCa may help to know the mechanisms of its formation and progression, as well as to identify new targets for the refinement of new treatment such as the pharmacogenomics approach.
Lingua originaleEnglish
pagine (da-a)1919-1933
Numero di pagine15
RivistaCANCER IMMUNOLOGY, IMMUNOTHERAPY
Volume58
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research

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