TY - JOUR
T1 - Polymorphisms of an Innate Immune Gene, Toll-Like Receptor 4, and AggressiveProstate Cancer Risk: A Systematic Review and Meta-analysis
AU - Balistreri, Carmela Rita
AU - Koutros, Stella
AU - Easton, Douglas F.
AU - Yeager, Meredith
AU - Neall, David E.
AU - Huang, Yi-Ling
AU - Weng, Pei-Hsuan
AU - Chen, Jen-Hau
AU - Donovanl, Jenny
AU - Hamdyl, Freddie C.
AU - Page, John H.
AU - Giles, Graham
AU - Easton, Douglas F.
AU - Severi, Gianluca
AU - Chanock, Stephen
AU - Eeles, Rosalind A.
AU - Muir, Kenneth R.
AU - Witte, John S.
AU - Xu, Jianfeng
AU - Smith, Jeffrey R.
AU - Chen, Yen-Ching
AU - Berndt, Sonja
AU - Shui, Irene M.
PY - 2014
Y1 - 2014
N2 - Background: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surfaceof several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associatedmolecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also wellrecognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but therelationship between TLR4 genotypes and aggressive PCa risk has not been evaluated by any systematicreviews.Methods: We performed a systematic review and meta-analysis of candidate-gene and genome-wideassociation studies analyzing this relationship and included only white population. Considering appropriatecriteria, only nine studies were analyzed in the meta-analysis, including 3,937 aggressive PCa and 7,382controls.Results: Using random effects model, no significant association was found in the ten TLR4 SNPs reportedby at least four included studies under any inheritance model (rs2737191, rs1927914, rs10759932,rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1554973). Pooled estimatesfrom another ten TLR4 SNPs reported by three studies also showed no significant association (rs10759930,rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, andrs7045953). Meta-regression revealed that study type was not a significant source of between-studyheterogeneity.Conclusions: TLR4 polymorphisms were not significantly associated with the risk of aggressive PCa
AB - Background: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surfaceof several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associatedmolecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also wellrecognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but therelationship between TLR4 genotypes and aggressive PCa risk has not been evaluated by any systematicreviews.Methods: We performed a systematic review and meta-analysis of candidate-gene and genome-wideassociation studies analyzing this relationship and included only white population. Considering appropriatecriteria, only nine studies were analyzed in the meta-analysis, including 3,937 aggressive PCa and 7,382controls.Results: Using random effects model, no significant association was found in the ten TLR4 SNPs reportedby at least four included studies under any inheritance model (rs2737191, rs1927914, rs10759932,rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1554973). Pooled estimatesfrom another ten TLR4 SNPs reported by three studies also showed no significant association (rs10759930,rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, andrs7045953). Meta-regression revealed that study type was not a significant source of between-studyheterogeneity.Conclusions: TLR4 polymorphisms were not significantly associated with the risk of aggressive PCa
UR - http://hdl.handle.net/10447/99934
M3 - Article
VL - 2
JO - PLoS One
JF - PLoS One
SN - 1932-6203
ER -