Polymorphisms of an Innate Immune Gene, Toll-Like Receptor 4, and AggressiveProstate Cancer Risk: A Systematic Review and Meta-analysis

Carmela Rita Balistreri, Stella Koutros, Douglas F. Easton, Meredith Yeager, David E. Neall, Yi-Ling Huang, Pei-Hsuan Weng, Jen-Hau Chen, Jenny Donovanl, Freddie C. Hamdyl, John H. Page, Graham Giles, John H. Page, Douglas F. Easton, Gianluca Severi, Stephen Chanock, Rosalind A. Eeles, Kenneth R. Muir, John S. Witte, Jianfeng XuJeffrey R. Smith, Yen-Ching Chen, Sonja Berndt, Irene M. Shui

Risultato della ricerca: Articlepeer review

15 Citazioni (Scopus)


Background: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surfaceof several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associatedmolecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also wellrecognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but therelationship between TLR4 genotypes and aggressive PCa risk has not been evaluated by any systematicreviews.Methods: We performed a systematic review and meta-analysis of candidate-gene and genome-wideassociation studies analyzing this relationship and included only white population. Considering appropriatecriteria, only nine studies were analyzed in the meta-analysis, including 3,937 aggressive PCa and 7,382controls.Results: Using random effects model, no significant association was found in the ten TLR4 SNPs reportedby at least four included studies under any inheritance model (rs2737191, rs1927914, rs10759932,rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1554973). Pooled estimatesfrom another ten TLR4 SNPs reported by three studies also showed no significant association (rs10759930,rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, andrs7045953). Meta-regression revealed that study type was not a significant source of between-studyheterogeneity.Conclusions: TLR4 polymorphisms were not significantly associated with the risk of aggressive PCa
Lingua originaleEnglish
Numero di pagine72
RivistaPLoS One
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1100.1100???
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